{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T23:32:12Z","timestamp":1709681532998},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T00:00:00Z","timestamp":1419206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Melanocytic naevi on the umbilicus have been described as a form of flexural naevi, with the most common feature being a \u2018nested and dyshesive pattern\u2019. We have encountered a distinct group of umbilical naevi with more significant atypia and prominent fibrosis, not reported previously. This study aimed to characterize these naevi more clearly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Eighty\u2010one umbilical naevi from 2000 to 2013 were reviewed retrospectively, 20 cases of which showed lamellar fibrosis and atypia and were designated as atypical umbilical naevi (<jats:styled-content style=\"fixed-case\">AUN<\/jats:styled-content>). Lamellar fibrosis in <jats:styled-content style=\"fixed-case\">AUN<\/jats:styled-content> was extensive and frequently entrapped dermal melanocytes, resulting in low\u2010grade cytological atypia (74% of cases) and impaired maturation (47%) of the dermal component. Other common features included bridging (95%), shoulder architecture (94%), lentiginous growth (85%) and high\u2010grade junctional cytological atypia (85%). \u2018Nested and dyshesive pattern\u2019 was observed in only 20% of <jats:styled-content style=\"fixed-case\">AUN<\/jats:styled-content>. Ki\u201067 immunostaining performed on 12 <jats:styled-content style=\"fixed-case\">AUN<\/jats:styled-content> revealed a consistently low proliferation index of &lt;1%. All <jats:styled-content style=\"fixed-case\">AUN<\/jats:styled-content> in this series lacked junctional confluence, florid pagetoid spread and dermal mitoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A subset of special site naevi in the umbilical region demonstrate characteristic lamellar fibrosis, architectural disorder and cytological atypia. Familiarity with these site\u2010related atypical features would avoid overdiagnosis of melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12503","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T11:39:01Z","timestamp":1407757141000},"page":"363-369","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Atypical umbilical naevi: histopathological analysis of 20 cases"],"prefix":"10.1111","volume":"66","author":[{"given":"David P","family":"Arps","sequence":"first","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R","family":"Fullen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"},{"name":"Department of Pathology Dermatology University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May P","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"},{"name":"Department of Pathology Dermatology University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1987.tb00478.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)80028-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318068420c"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.10.046"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00622.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00263.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000152022.81651.a7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00159.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70235-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb00326.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027005215.x"},{"key":"e_1_2_7_13_1","first-page":"371","article-title":"Morphologic and immunohistochemical features of breast nevi","volume":"54","author":"Nicolau AA","year":"2013","journal-title":"Rom. 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