{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:53:47Z","timestamp":1760043227522,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T00:00:00Z","timestamp":1414627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2013-47416-R"],"award-info":[{"award-number":["SAF2013-47416-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003545","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","award":["SAF2008-03871"],"award-info":[{"award-number":["SAF2008-03871"]}],"id":[{"id":"10.13039\/501100003545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002704","name":"Fundaci\u00f3n Cient\u00edfica Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Immunoglobulin light\u2010chain expression is used routinely as an indirect marker of clonality for recognizing B cell lymphoproliferative disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Here we describe four floral follicular hyperplasia cases in the gastrointestinal tract (appendix and rectum) of children (4 to 6\u00a0years). Immunohistochemical studies revealed lambda light\u2010chain restriction that was associated with polyclonal IgH pattern. Clinical features and follow\u2010up of the patients did not reveal any other systemic symptoms, laboratory abnormalities or organ alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recognition of this phenomenon is useful in the diagnosis of nodular lymphoid hyperplasia of the gastrointestinal tract, for avoiding overdiagnosis of lymphoid malignancies, and raises concerns that the identification of light\u2010chain restriction is not necessarily a marker of monoclonality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12511","type":"journal-article","created":{"date-parts":[[2014,8,16]],"date-time":"2014-08-16T10:15:06Z","timestamp":1408184106000},"page":"805-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Childhood florid follicular hyperplasia with immunoglobulin light\u2010chain restriction in the gastrointestinal tract"],"prefix":"10.1111","volume":"65","author":[{"given":"Azahara","family":"Martinez\u2010Lopez","sequence":"first","affiliation":[{"name":"Department of Pathology Hospital Virgen de la Salud Toledo Spain"},{"name":"Department of Pathology Hospital Universitario Marques de Valdecilla IDIVAL Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Montes\u2010Moreno","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitario Marques de Valdecilla IDIVAL Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitario Son Espases Palma de Mallorca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Luis","family":"Afonso\u2010Martin","sequence":"additional","affiliation":[{"name":"Department of Pathology Complejo Hospitalario Universitario Insular Materno Infantil Las Palmas de Gran Canaria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Mazorra","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitario Marques de Valdecilla IDIVAL Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Gonzalez de Villambrosia","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario Marques de Valdecilla IDIVAL Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Batlle","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario Marques de Valdecilla IDIVAL Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M","family":"Grogan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Arizona Tucson AZ 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