{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:26:27Z","timestamp":1762503987047},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T00:00:00Z","timestamp":1414713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Congenital pulmonary airway malformation (<jats:styled-content style=\"fixed-case\">CPAM<\/jats:styled-content>) is a rare developmental anomaly of the lung. Here, we report a case of mucinous adenocarcinoma arising in <jats:styled-content style=\"fixed-case\">CPAM<\/jats:styled-content>. A 23\u2010month\u2010old boy underwent a thoracoscopic lobectomy of the left upper lobe of the lung based on a presumptive diagnosis of asymptomatic <jats:styled-content style=\"fixed-case\">CPAM<\/jats:styled-content>, found in antenatal sonogram.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Histologically, the lesion was consistent with <jats:styled-content style=\"fixed-case\">CPAM<\/jats:styled-content>, Stocker type I. In addition, multiple foci ranging from mucinous epithelial hyperplasia to mucinous adenocarcinoma were detected. All lesions shared the same immunoprofile with the expression of cytokeratin (<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>) 20, <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>5<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>, and human epidermal growth factor receptor2 (HER2), but were negative for <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>7, transcription factor 1 (TTF\u20101), <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">CDX<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>1) and anaplastic lymphoma kinase (ALK). <jats:italic>K\u2010<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content><\/jats:italic> point mutation (G12V) was also detected in all micro\u2010dissected mucinous lesions but <jats:italic><jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content><\/jats:italic> mutation was not found. All lesions were consistent with mucinous adenocarcinoma. The patient's clinical course has been uneventful during the 12\u2010months follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This interesting case demonstrated that multiple foci in <jats:styled-content style=\"fixed-case\">CPAM<\/jats:styled-content> can synchronously transform into malignancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12515","type":"journal-article","created":{"date-parts":[[2014,7,26]],"date-time":"2014-07-26T12:43:43Z","timestamp":1406378623000},"page":"926-932","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Multifocal synchronous mucinous adenocarcinomas arising in congenital pulmonary airway malformation: a case report with molecular study"],"prefix":"10.1111","volume":"65","author":[{"given":"Moon\u2010Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pathology Seoul National University Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Hyun","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Seoul National University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Hye","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital Seoul South Korea"},{"name":"Department of Pathology Seoul National University College of Medicine Seoul South\u00a0Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.19.1.1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.2177"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513815.2013.842272"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2013.06.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.232"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00011705"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2165"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(77)80078-6"},{"key":"e_1_2_7_10_1","first-page":"2597","article-title":"Mucinous bronchioloalveolar carcinoma with k\u2010ras mutation arising in type 1 congenital cystic adenomatoid malformation: a case report with review of the literature","volume":"6","author":"Ishida M","year":"2013","journal-title":"Int. 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