{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:42Z","timestamp":1787014302158,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    Tropical sprue (\n                    <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>\n                    ) is a malabsorption syndrome of presumed infectious aetiology that affects residents of (or visitors to) the tropics. The histological changes of\n                    <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>\n                    are similar to those of coeliac disease, with increased intraepithelial lymphocytes being central to both. Unlike in coeliac disease, however, a completely flat small bowel biopsy is uncommon in\n                    <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>\n                    .\n                    <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>\n                    typically involves the terminal ileum, whereas coeliac disease does not. Small intestinal bacterial overgrowth (\n                    <jats:styled-content style=\"fixed-case\">SIBO<\/jats:styled-content>\n                    ) has been defined as an increase in number and\/or a change in the type of bacteria in the upper gut. Conditions that predispose to\n                    <jats:styled-content style=\"fixed-case\">SIBO<\/jats:styled-content>\n                    are largely those that decrease or interfere with small bowel motility. The mucosal histology is variable, and may include modest villous blunting accompanied by increased lamina propria and epithelial inflammation. Autoimmune enteropathy (\n                    <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>\n                    ) is a family of rare diseases that share common themes such as immunodeficiency states and autoantibodies.\n                    <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>\n                    cases typically have marked villous atrophy similar to that in fully developed coeliac disease, but they lack the intense surface epithelial lymphocytosis. Apoptosis and lymphocyte infiltration at the base of the crypts, crypt abscesses and cryptitis are also seen. Patients with anti\u2010goblet cell antibodies can have a lack of goblet cells, endocrine cells, and Paneth cells.\n                  <\/jats:p>","DOI":"10.1111\/his.12522","type":"journal-article","created":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T11:58:50Z","timestamp":1411041530000},"page":"29-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["The biopsy pathology of non\u2010coeliac enteropathy"],"prefix":"10.1111","volume":"66","author":[{"given":"Joel K","family":"Greenson","sequence":"first","affiliation":[{"name":"University of Michigan Medical Center Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/ajcn\/21.9.984","article-title":"Syndrome of tropical sprue in India","volume":"21","author":"Baker SJ","year":"1968","journal-title":"Am. 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