{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:48:07Z","timestamp":1788979687544,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T00:00:00Z","timestamp":1414454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["NIH\/NCIP50CA095103"],"award-info":[{"award-number":["NIH\/NCIP50CA095103"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Recently, we described a series of pancreatic neuroendocrine tumours (Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s) featuring prominent stromal fibrosis, which we called sclerosing Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s. The aim of this study was to examine the pathological, immunophenotypic and clinical differences between sclerosing and non\u2010sclerosing Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>One hundred and six Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s were identified, of which 15 (14%) were sclerosing <jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s. Tissue microarrays containing 44 non\u2010sclerosing and five sclerosing Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s, as well as sections from 10 additional sclerosing tumours, were immunohistochemically labelled for serotonin, <jats:styled-content style=\"fixed-case\">CDX<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17, and islet 1. Sclerosing Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s were smaller (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.045) and more likely to show an infiltrative growth pattern (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) than non\u2010sclerosing Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s. They were frequently associated with a large pancreatic duct, causing duct stenosis. Additionally, we found significantly increased expression of the small intestinal <jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content> markers serotonin, <jats:styled-content style=\"fixed-case\">CDX<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17 in sclerosing Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) as compared with non\u2010sclerosing Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s. No difference in clinical outcome was found; however, more sclerosing Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s were stage <jats:styled-content style=\"fixed-case\">IIB<\/jats:styled-content> or above (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.035), with lymph node metastasis being seen in three of nine sclerosing Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s with a tumour size of &lt;20\u00a0mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sclerosing Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s have distinct pathological features and biomarker expression profiles. In addition, lymph node metastasis can be present even with small sclerosing Pan<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12535","type":"journal-article","created":{"date-parts":[[2014,10,12]],"date-time":"2014-10-12T08:12:54Z","timestamp":1413101574000},"page":"225-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Cadherin 17 is frequently expressed by \u2018sclerosing variant\u2019 pancreatic neuroendocrine tumour"],"prefix":"10.1111","volume":"66","author":[{"given":"Adam","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse P","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Surgery, Surgical Oncology Vanderbilt University 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