{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:21:42Z","timestamp":1778498502374,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T00:00:00Z","timestamp":1421884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30971137, 81272605"],"award-info":[{"award-number":["30971137, 81272605"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>High expression of carbonic anhydrase <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CA IX<\/jats:styled-content>) has been reported in clear cell renal cell carcinoma (cc<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>); few studies have reported <jats:styled-content style=\"fixed-case\">CA IX<\/jats:styled-content> expression in other tumours with predominantly clear cell morphology. The aim of study was to examine the expression and diagnostic implications of <jats:styled-content style=\"fixed-case\">CA IX<\/jats:styled-content> in these latter tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>An immunohistochemical study was performed of 159 tumours with predominantly clear cell morphology. The results showed that, in addition to primary (25\/25) and metastatic (10\/11) cc<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CA IX<\/jats:styled-content> was also expressed in breast (2\/2), pulmonary (3\/5) and hepatic (1\/4) clear cell carcinoma, urothelial carcinoma with clear cell change (3\/6), clear cell meningioma (4\/6) and ependymoma (2\/3), haemangioblastoma (10\/10), and clear cell hidradenoma (5\/6). However, while strong and diffuse positivity for <jats:styled-content style=\"fixed-case\">CA IX<\/jats:styled-content> was observed in cc<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>, clear cell breast carcinoma, haemangioblastoma, and clear cell hidradenoma, the other cases showed predominantly focal positivity for <jats:styled-content style=\"fixed-case\">CA IX<\/jats:styled-content>. In particular, <jats:styled-content style=\"fixed-case\">CA IX<\/jats:styled-content> staining was often seen at the periphery of necrotic areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that strong and diffuse <jats:styled-content style=\"fixed-case\">CA IX<\/jats:styled-content> expression may be useful for differentiating cc<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> from several clear cell tumours, with the exception of clear cell breast carcinoma, haemangioblastoma, and clear cell hidradenoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12536","type":"journal-article","created":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T15:32:15Z","timestamp":1417102335000},"page":"685-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Expression and diagnostic implications of carbonic anhydrase <scp>IX<\/scp> in several tumours with predominantly clear cell morphology"],"prefix":"10.1111","volume":"66","author":[{"given":"Xu\u2010Yong","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pathology the First Affiliated Hospital and College of Basic Medical Sciences China Medical University Shenyang China"},{"name":"Institute of Pathology and Pathophysiology China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology the First Affiliated Hospital and College of Basic Medical Sciences China Medical University Shenyang China"},{"name":"Institute of Pathology and Pathophysiology China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology the First Affiliated Hospital and College of Basic Medical Sciences China Medical University Shenyang China"},{"name":"Institute of Pathology and Pathophysiology China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu\u2010Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology the First Affiliated Hospital and College of Basic Medical Sciences China Medical University Shenyang China"},{"name":"Institute of Pathology and Pathophysiology China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Fushun Mining Bureau General Hospital Fushun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"En\u2010Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology the First Affiliated Hospital and College of Basic Medical Sciences China Medical University Shenyang China"},{"name":"Institute of Pathology and Pathophysiology China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Chen","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology the First Affiliated Hospital and College of Basic Medical Sciences China Medical University Shenyang China"},{"name":"Institute of Pathology and Pathophysiology China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910540218"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520310062031"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-sup-040025"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318181b828"},{"key":"e_1_2_8_6_1","first-page":"2827","article-title":"Identification of the MN\/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney","volume":"57","author":"Liao SY","year":"1997","journal-title":"Cancer Res."},{"key":"e_1_2_8_7_1","volume-title":"World Health Organization classification of tumours: pathology and genetics of tumours of the urinary system and male genital organs","author":"Eble JN","year":"2004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1178-7"},{"key":"e_1_2_8_9_1","first-page":"663","article-title":"Hypoxia inducible factor\u20101 alpha and carbonic anhydrase IX overexpression are associated with poor survival in breast cancer patients","volume":"17","author":"Kaya AO","year":"2012","journal-title":"J. BUON."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02523.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-2-249"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.09.036"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365599.2012.685493"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04074.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e318214dd4f"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182147fa8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/PAI.0b013e3181dd35d2","article-title":"Clear cell meningioma: a clinicopathologic study of 18 tumors and examination of the use of CD10, CA9, and RCC antibodies to distinguish between clear cell meningioma and metastatic clear cell renal cell carcinoma","volume":"18","author":"Prayson RA","year":"2010","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPPR57HNJMSLZ"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182a266c1"},{"key":"e_1_2_8_20_1","first-page":"1279","article-title":"GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression","volume":"26","author":"Pinheiro C","year":"2011","journal-title":"Histol. Histopathol."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-010-0938-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2232-0"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12536","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T12:39:51Z","timestamp":1696250391000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,22]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/his.12536"],"URL":"https:\/\/doi.org\/10.1111\/his.12536","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,22]]},"assertion":[{"value":"2014-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}