{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:00:59Z","timestamp":1780491659756,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Aims<\/jats:title>Atypical ductal hyperplasia (ADH<\/jats:styled-content>) rarely arises in gynaecomastia. We set out to understand more clearly the clinical, histological and immunohistochemical features of ADH<\/jats:styled-content> in this setting.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>Twenty\u2010five cases of ADH<\/jats:styled-content> arising in gynaecomastia, nine cases of ductal carcinoma in situ<\/jats:italic> (DCIS<\/jats:styled-content>) and 36 cases of gynaecomastia with usual ductal hyperplasia (UDH<\/jats:styled-content>) were studied. Reviews of clinical, morphological and immunohistochemical findings were performed. The extent of cytokeratin 5\/6 (CK<\/jats:styled-content>5\/6) luminal epithelial cell staining was assessed (0%\u00a0=\u00a00, <10%\u00a0=\u00a01, 10\u201350%\u00a0=\u00a02 and >50%\u00a0=\u00a03). Oestrogen receptor (ER<\/jats:styled-content>) was evaluated using the H\u2010scoring system. The average age of ADH<\/jats:styled-content> patients was 35\u00a0years (range 14\u201378). ADH<\/jats:styled-content> was bilateral in 20% and less frequent in active gynaecomastia (24%). ADH<\/jats:styled-content> often showed a cribriform pattern (72%), with less nuclear variation\/size and similar frequency of mitoses than UDH<\/jats:styled-content> cells. CK<\/jats:styled-content>5\/6 luminal epithelial staining was decreased in ADH<\/jats:styled-content> (68%) versus UDH<\/jats:styled-content> (11%). ADH<\/jats:styled-content> showed high ER<\/jats:styled-content> expression compared to UDH<\/jats:styled-content> (H score >270 in 88% and 14%, respectively).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>ADH<\/jats:styled-content> in gynaecomastia can be distinguished from UDH<\/jats:styled-content> by morphological and immunhistochemical features. We also identified a subset of young patients (<25\u00a0years) with extensive bilateral ADH<\/jats:styled-content>. More studies are needed to characterize this patient subset more clearly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12545","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T14:07:34Z","timestamp":1410530854000},"page":"398-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Elucidating encounters of atypical ductal hyperplasia arising in gynaecomastia"],"prefix":"10.1111","volume":"66","author":[{"given":"Justin M","family":"Wells","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York Presbyterian Hospital\u2013Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York Presbyterian Hospital\u2013Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula S","family":"Ginter","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York Presbyterian Hospital\u2013Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela T","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York Presbyterian Hospital\u2013Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra J","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York Presbyterian Hospital\u2013Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"284","volume-title":"Rosen's breast pathology","author":"Hoda SA","year":"2014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp070677"},{"key":"e_1_2_8_4_1","first-page":"388","article-title":"Pathological Findings in gynecomastia: analysis of 5113 breasts","volume":"37","author":"Lapid O","year":"2013","journal-title":"Ann. 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