{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:47:54Z","timestamp":1790232474184,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T00:00:00Z","timestamp":1419206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch Digestive Diseases Foundation","award":["WO 11-58"],"award-info":[{"award-number":["WO 11-58"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>In this study, we aimed to evaluate the use of typical histological features of both the revised original (1999) and simplified (2008) criteria in the diagnosis of autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>) in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We performed a detailed histopathological evaluation of the pretreatment biopsies of 63 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients, and used biopsies of 62 untreated chronic viral hepatitis patients [hepatitis B (<jats:italic>n<\/jats:italic>\u00a0=\u00a021) or hepatitis C (<jats:italic>n<\/jats:italic>\u00a0=\u00a041)] as a reference cohort. Biopsies were systematically reviewed for inflammation, fibrosis and the presence of interface hepatitis, plasma cells, rosettes and emperipolesis with a well\u2010defined assessment method. <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> biopsies showed more interface hepatitis (87% versus 63%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), more plasma cell\u2010rich infiltrates (48% versus 27%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), more rosettes (49% versus 23%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) and more emperipolesis (78% versus 50%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) than chronic viral hepatitis biopsies. Emperipolesis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and rosettes (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) were superior to plasma cells and interface hepatitis as independent predictors for <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>. Moderate to severe lymphocytic cholangitis was found in 28% of <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Emperipolesis and rosette formation are superior histological predictors of <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> than the classic hallmark features of interface hepatitis and plasma cells. In addition, moderate to severe lymphocytic cholangitis does not preclude the diagnosis of <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12558","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T10:38:06Z","timestamp":1411727886000},"page":"351-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Assessment of the histopathological key features in autoimmune hepatitis"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4066-7593","authenticated-orcid":false,"given":"Ynto S","family":"de Boer","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin M J","family":"van Nieuwkerk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit I","family":"Witte","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J J","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Bouma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Bloemena","sequence":"additional","affiliation":[{"name":"Department of Pathology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.08.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-200205000-00007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22322"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22513"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.06.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22825"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150403"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)91081-R"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850166284"},{"key":"e_1_2_8_12_1","unstructured":"The Medical Research Involving Human Subjects Act (Wet medisch\u2010wetenschappelijk onderzoek met mensen WMO; text in Dutch). 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