{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:42:41Z","timestamp":1790678561076,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T00:00:00Z","timestamp":1419206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To report a previously undescribed phenomenon of incidentally detected microscopic proliferations of sex cord cells, often mimicking adult granulosa cell tumour or sex cord tumour with annular tubules, in extraovarian locations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The six cases were in patients aged 23\u201358\u00a0years. The proliferations were located in the fallopian tube in three cases, and in paraovarian connective tissues, the pelvic side wall, and appendiceal serosa (one case each). Microscopically, they were typically composed of well\u2010demarcated nests of regular cells with round\/ovoid vesicular nuclei, some containing grooves. Microfollicular and\/or cribriform arrangements were present in three cases. In five cases, the sex cord lineage was confirmed by positive staining with inhibin and\/or calretinin and other sex cord markers. <jats:italic><jats:styled-content style=\"fixed-case\">FOXL<\/jats:styled-content>2<\/jats:italic> mutation analysis was performed in one case, but was inconclusive. Bilateral oophorectomies and bilateral cystectomies were performed in three cases and one case respectively; there was no sex cord\u2013stromal neoplasm in the removed ovaries. In the two cases in which the ovaries were not removed, imaging showed no suspicious features. Follow\u2010up in four cases (11\u00a0months\u20136\u00a0years) has been uneventful.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The pathogenesis of these microscopic extraovarian sex cord proliferations is unknown, but they may represent non\u2010neoplastic proliferations of embryonic remnants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12580","type":"journal-article","created":{"date-parts":[[2014,10,12]],"date-time":"2014-10-12T08:13:27Z","timestamp":1413101607000},"page":"555-564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Microscopic extraovarian sex cord proliferations: an undescribed phenomenon"],"prefix":"10.1111","volume":"66","author":[{"given":"W Glenn","family":"McCluggage","sequence":"first","affiliation":[{"name":"Department of Pathology Belfast Health and Social Care Trust Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin J R","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Pathology King Edward Memorial Hospital Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Iacobelli","sequence":"additional","affiliation":[{"name":"Department of Pathology King Edward Memorial Hospital Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Pathology King Edward Memorial Hospital Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen R","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K","family":"Heatley","sequence":"additional","affiliation":[{"name":"Department of Pathology St James's Hospital Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Boyde","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Hospital Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaise A","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University Health Network University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,22]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"254","article-title":"Extra\u2010ovarian granulosa cell tumour","volume":"41","author":"Reddy DB","year":"1963","journal-title":"J. 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