{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:24:58Z","timestamp":1790958298813,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T00:00:00Z","timestamp":1421884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports and Science and Technology of Japan","doi-asserted-by":"crossref","award":["21590366"],"award-info":[{"award-number":["21590366"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To characterize serum amyloid A (<jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>)\u2010positive hepatocellular neoplasms\/nodules arising in alcoholic cirrhosis, which are detected as hypervascular hepatocellular nodules resembling hepatocellular carcinoma on imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Fifty\u2010three hepatocellular nodules were examined with immunostaining for <jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>, glutamine synthetase and glypican\u20103 in 23 patients (four women and 19 men) with alcoholic cirrhosis. Sixteen nodules were examined with magnetic resonance imaging with gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid enhancement (<jats:styled-content style=\"fixed-case\">EOB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>). Somatic mutations in <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content><\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">GNAS<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3<\/jats:italic> were examined in 19 nodules. Thirty\u2010six nodules in 18 patients were diagnosed as <jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>\u2010positive hepatocellular neoplasms\/nodules, and the remaining 17 nodules in eight patients were <jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>\u2010negative focal nodular hyperplasia (<jats:styled-content style=\"fixed-case\">FNH<\/jats:styled-content>)\u2010like nodules. <jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>\u2010positive hepatocellular neoplasms\/nodules showed significantly more extensive sinusoidal dilatation, inflammatory reaction, abnormally thick arteries and cellular atypia than <jats:styled-content style=\"fixed-case\">FNH<\/jats:styled-content>\u2010like nodules (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Eight <jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>\u2010positive hepatocellular neoplasms\/nodules (67%) showed slight hypointensity in the hepatobiliary phase on <jats:styled-content style=\"fixed-case\">EOB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, whereas all four <jats:styled-content style=\"fixed-case\">FNH<\/jats:styled-content>\u2010like nodules showed iso\u2010intensity (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). <jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3<\/jats:italic> mutations were detected in two of 17 <jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>\u2010positive hepatocellular neoplasms\/nodules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that approximately two\u2010thirds of hypervascular hepatocellular nodules arising in alcoholic cirrhosis were <jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>\u2010positive hepatocellular neoplasms\/nodules, which show different findings on the <jats:styled-content style=\"fixed-case\">EOB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. <jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3<\/jats:italic> mutations were detected in 11.8% of <jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>\u2010positive hepatocellular neoplasms\/nodules, supporting a neoplastic nature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12588","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T13:20:02Z","timestamp":1413379202000},"page":"836-845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Clinicopathological characteristics of serum amyloid A\u2010positive hepatocellular neoplasms\/nodules arising in alcoholic cirrhosis"],"prefix":"10.1111","volume":"66","author":[{"given":"Motoko","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Human Pathology Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihide","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"},{"name":"Department of Radiology Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Sawai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ikeda Municipal Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ikeda Municipal Hospital Osaka 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