{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:43:26Z","timestamp":1782254606798,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T00:00:00Z","timestamp":1423008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Synovial sarcomas may arise within retroperitoneal or pelvic tissues or, more rarely, within the luminal gastrointestinal tract. This case series aims to demonstrate how such primary abdominal synovial sarcomas may particularly mimic gastrointestinal stromal tumour (<jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>) on both morphological and immunohistochemical grounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Four cases of primary abdominal synovial sarcoma were reviewed morphologically and with immunohistochemistry, fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridization with an <jats:italic><jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>18<\/jats:italic> break\u2010apart probe, and <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic>\/<jats:italic><jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content><\/jats:italic> mutation analysis. The four patients comprised two males and two females, with a median age of 42\u00a0years (range: 17\u201359\u00a0years). Two synovial sarcomas arose within the stomach, one within the small\u2010intestine mesentery, and the fourth within the retroperitoneum. All four tumours showed only a monophasic spindle cell component in the tissues available for review. All four tumours showed <jats:styled-content style=\"fixed-case\">DOG<\/jats:styled-content>1 immunopositivity, and three coexpressed <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>117. Three tested cases did not show activating <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic> or <jats:italic><jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content><\/jats:italic> mutations, whereas all four cases showed chromosomal rearrangement of <jats:italic><jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>18<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A diagnosis of synovial sarcoma should be considered particularly if an abdominal spindle cell neoplasm shows a haemangiopericytomatous pattern and diffuse <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>99 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56 immunopositivity. A confident distinction between abdominal synovial sarcoma and <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content> requires <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic>\/<jats:italic><jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content><\/jats:italic> mutation analyses and specific molecular testing for synovial sarcoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12593","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T02:53:12Z","timestamp":1414378392000},"page":"974-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Abdominal monophasic synovial sarcoma is a morphological and immunohistochemical mimic of gastrointestinal stromal tumour"],"prefix":"10.1111","volume":"66","author":[{"given":"Newton A C S","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Histopathology Bristol Royal Infirmary Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Pathology Royal Liverpool University Hospital Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Gloucestershire Cellular Pathology Laboratory Cheltenham General Hospital Cheltenham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.01950.x"},{"key":"e_1_2_9_3_1","first-page":"211","article-title":"Retroperitoneal synovial sarcoma: a clinicopathological study of 6 cases","volume":"13","author":"Chatzipantelis P","year":"2008","journal-title":"J. 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