{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:35:05Z","timestamp":1790134505392,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the presence of multi\u2010layered epithelium (<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>) and to compare the distribution, size and morphology of the oesophageal submucosal glands (<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>) beneath reflux exposed metaplastic columnar mucosa with those of normal squamous epithelium in patients with columnar\u2010lined oesophagus (<jats:styled-content style=\"fixed-case\">CLO<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In eight oesophageal resection specimens, the <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> of the metaplastic segments were significantly larger than those in the squamous segments of patients with <jats:styled-content style=\"fixed-case\">CLO<\/jats:styled-content> (0.81 versus 0.56\u00a0mm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a0&lt;0.001). There was an accumulation of <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> close to the neosquamocolumnar junction (<jats:styled-content style=\"fixed-case\">NSCJ<\/jats:styled-content>), as indicated by a higher median frequency of <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> (0.080 <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\/mm) compared with that of the squamous (0.013 <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\/mm) and metaplastic segments (0.031 <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\/mm) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.022). The frequency of <jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content> was significantly higher in the metaplastic compared with the normal squamous segments (1\/158\u00a0mm and 1\/341\u00a0mm, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.028) and <jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content> was found almost exclusively (96%) in direct connection with the excretory ducts of <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hyperplasia of <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> in the metaplastic segment, accumulation of <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> near the <jats:styled-content style=\"fixed-case\">NSCJ<\/jats:styled-content>, the presence of <jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content> in connection with the excretory ducts of <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> and metaplasia are all reflux\u2010induced morphological changes, possibly induced by stimulation of progenitors in the excretory ducts of the <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12604","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T09:25:43Z","timestamp":1415438743000},"page":"726-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hyperplasia of the submucosal glands of the columnar\u2010lined oesophagus"],"prefix":"10.1111","volume":"66","author":[{"given":"Ester","family":"L\u00f6rinc","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Lund University and Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"\u00d6berg","sequence":"additional","affiliation":[{"name":"Department of Surgery Helsingborg Hospital Clinical Sciences Lund Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103042"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06046.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1550-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.135.6.651"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200111000-00006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03411-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04180.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200105000-00002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000100102"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1076\/ejom.39.3.0163"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(93)70175-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70337-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/dote\/11.2.89","article-title":"Gastroesophageal reflux triggers proliferative activity of the submucosal glands in the canine esophagus","volume":"11","author":"Nieuwenhove Y","year":"1998","journal-title":"Dis. 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