{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:48:07Z","timestamp":1788979687997,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Cadherin 17 (<jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17) is expressed primarily in normal intestinal epithelium and digestive tract tumours, and has limited expression in other neoplasms. The aims of this study were to examine <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17 expression in well\u2010differentiated neuroendocrine tumours (<jats:styled-content style=\"fixed-case\">WDNET<\/jats:styled-content>s) from various primary sites, representing the foregut, midgut, and hindgut, and tumours metastasizing to the liver, and to correlate the differences between the expression of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17, <jats:styled-content style=\"fixed-case\">CDX<\/jats:styled-content>2, and thyroid transcription factor 1 (<jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We investigated <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17 immunohistochemical expression in 150 primary <jats:styled-content style=\"fixed-case\">WDNET<\/jats:styled-content>s from eight anatomical sites, including 68 from the foregut, 70 from the midgut, and 12 from the hindgut, and 15 metastases. <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17 immunoreactivity increased significantly from foregut to hindgut <jats:styled-content style=\"fixed-case\">WDNET<\/jats:styled-content>s (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Pancreatic <jats:styled-content style=\"fixed-case\">WDNET<\/jats:styled-content>s expressed <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17 at a significantly higher frequency than other foregut tumours. Within the midgut, appendiceal and small\u2010intestinal <jats:styled-content style=\"fixed-case\">WDNET<\/jats:styled-content>s were more frequently positive for <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17 than for <jats:styled-content style=\"fixed-case\">CDX<\/jats:styled-content>2. All hindgut <jats:styled-content style=\"fixed-case\">WDNET<\/jats:styled-content>s expressed <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17, in contrast to <jats:styled-content style=\"fixed-case\">CDX<\/jats:styled-content>2 (positive in one rectal case). <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17 expression in liver metastases was similar to that of the primary tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study is the first to comprehensively examine <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17 expression in <jats:styled-content style=\"fixed-case\">WDNET<\/jats:styled-content>s from different sites. <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17 is a sensitive marker for midgut <jats:styled-content style=\"fixed-case\">WDNET<\/jats:styled-content>s, and the <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>17+\/<jats:styled-content style=\"fixed-case\">CDX<\/jats:styled-content>2\u2212\/<jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>1\u2212 phenotype was found to be sensitive (92%) and specific (91%) for hindgut <jats:styled-content style=\"fixed-case\">WDNET<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12610","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T14:07:57Z","timestamp":1415714877000},"page":"1010-1021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Expression of cadherin 17 in well\u2010differentiated neuroendocrine tumours"],"prefix":"10.1111","volume":"66","author":[{"given":"Anthony N","family":"Snow","sequence":"first","affiliation":[{"name":"Department of Pathology Rhode Island Hospital and Alpert Medical School of Brown University Providence RI USA"},{"name":"Department 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