{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:08:24Z","timestamp":1788869304803,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"crossref","award":["179571"],"award-info":[{"award-number":["179571"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"crossref","award":["39444"],"award-info":[{"award-number":["39444"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Norwegian Cancer Society","award":["33260"],"award-info":[{"award-number":["33260"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Manual counting of the fraction of Ki\u201067\u2010positive cells (the Ki\u201067 index) in 1000 tumour cells is considered the \u2018gold standard\u2019 to predict prognosis in mantle cell lymphoma (\n                      <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>\n                      ). This time\u2010consuming method is replaced by the faster, but less accurate, semiquantitative estimation in routine practice. The aim of this study was to investigate the use of computerized image analysis software for scoring of Ki\u201067 in\n                      <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We developed an automated method for determining the Ki\u201067 index by computerized image analysis and tested it using a cohort of 62\n                      <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>\n                      patients. The data were compared to Ki\u201067 scores obtained by semiquantitative estimation and image\u2010based manual counting. When using the Ki\u201067 index as a continuous parameter, both image\u2010based manual counting and computerized image analysis were related inversely to survival (\n                      <jats:italic>P\u00a0=\u00a0<\/jats:italic>\n                      0.020 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.025, respectively). Ki\u201067 index obtained by semiquantitative estimation was not associated significantly with survival (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.093). The results were validated in a second patient cohort with similar results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Computerized image analysis of the Ki\u201067 index in\n                      <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>\n                      is an attractive alternative to semiquantitative estimation and can be introduced easily in a routine diagnostic setting for risk stratification in\n                      <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.12624","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T09:12:17Z","timestamp":1417165937000},"page":"62-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Computerized image analysis of the Ki\u201067 proliferation index in mantle cell lymphoma"],"prefix":"10.1111","volume":"67","author":[{"given":"Yngvild N","family":"Blaker","sequence":"first","affiliation":[{"name":"Centre for Cancer Biomedicine Faculty of Medicine University of Oslo Oslo Norway"},{"name":"Department of Immunology Institute for Cancer Research Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Brodtkorb","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biomedicine Faculty of Medicine University of Oslo Oslo Norway"},{"name":"Department of Immunology Institute for Cancer Research Oslo 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