{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:29:20Z","timestamp":1769524160795,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,8]],"date-time":"2015-02-08T00:00:00Z","timestamp":1423353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To estimate the likelihood of the upgrade for atypical ductal hyperplasia (<jats:styled-content style=\"fixed-case\">ADH<\/jats:styled-content>) diagnosed on a core needle biopsy of a mammographically detected lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A total of 203 consecutive <jats:styled-content style=\"fixed-case\">ADH<\/jats:styled-content> cases diagnosed on core biopsy in mammographically detected lesions and having subsequent surgical excision were reviewed. The pathological features of <jats:styled-content style=\"fixed-case\">ADH<\/jats:styled-content> were assessed with multivariable logistic regression to predict the likelihood of upgrade for these patients. A nomogram was created using statistically significant variables. A corresponding formula was created to calculate the risk of upgrade. This risk was divided further into low, intermediate and high. A total of 57 (28.1%) cases had upgrade. A nomogram was created that included age, menopausal status, hormone therapy status, personal history of breast cancer, number of involved cores, solid growth pattern, size of largest focus and mammographic mass versus calcifications. The nomogram had an area under the receiver operating characteristic curve of 0.775.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have developed a user\u2010friendly nomogram that uses easily recognized variables to calculate the likelihood of upgrade for <jats:styled-content style=\"fixed-case\">ADH<\/jats:styled-content>. The nomogram could assist the treating surgeon in decision\u2010making, particularly when the patient is at risk for surgical intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12635","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T13:47:57Z","timestamp":1418996877000},"page":"106-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Nomogram to predict the likelihood of upgrade of atypical ductal hyperplasia diagnosed on a core needle biopsy in mammographically detected lesions"],"prefix":"10.1111","volume":"67","author":[{"given":"Thaer","family":"Khoury","sequence":"first","affiliation":[{"name":"Department of Pathology Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanna","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiology Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maochun","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Roswell Park Cancer Institute Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Pathology Roswell Park Cancer Institute Buffalo NY USA"},{"name":"Department of Pathology University of Rochester Medical Center Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850601)55:11<2698::AID-CNCR2820551127>3.0.CO;2-A"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900201)65:3<518::AID-CNCR2820650324>3.0.CO;2-O"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900915)66:14 <1326::AID-CNCR2820661405>3.0.CO;2-P"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9134(98)80051-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00181-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00727-9"},{"key":"e_1_2_6_8_1","first-page":"297","article-title":"Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types","volume":"6","author":"Marshall LM","year":"1997","journal-title":"Cancer Epidemiol. 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