{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T04:57:42Z","timestamp":1768712262230,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Aims<\/jats:title>The available evidence indicates that most non\u2010uterine high\u2010grade serous carcinomas (HGSC<\/jats:styled-content>s) arise from the fallopian tube (FT<\/jats:styled-content>), but approaches to primary site assignment have not evolved to reflect this. The aim of this study was to assess the application of recently proposed criteria for site assignment.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>One hundred and fifty\u2010one HGSC<\/jats:styled-content>s from four centres were reviewed retrospectively. Sixty\u2010three of 80 (79%) chemonaive (CN<\/jats:styled-content>) and 45 of 71 (68%) post\u2010neoadjuvant chemotherapy (NACT<\/jats:styled-content>) cases were assigned as FT<\/jats:styled-content> primaries with the new criteria, whereas 58 of 80 (73%) and 45 of 71 (63%) were assigned as ovarian primaries with traditional criteria (P<\/jats:italic>\u00a0<\u00a00.0001). Of 111 prospectively collected HGSC<\/jats:styled-content>s, with consistent detailed fimbrial examination, 44 of 53 (83%) CN<\/jats:styled-content> and 44 of 58 (76%) NACT<\/jats:styled-content> cases were assigned as FT<\/jats:styled-content> primaries. The reproducibility of site assignment was tested in a subset of 50 cases: all four reviewing pathologists agreed on the primary site in 48 of 50 (96%) cases, and three of four agreed in 49 of 50 (98%) cases. Of the 53 prospectively studied CN<\/jats:styled-content> cases, bilateral ovarian involvement (62%) was significantly more frequent than bilateral tubal involvement (12%, P<\/jats:italic>\u00a0<\u00a00.0001), further supporting a tubal origin and ovarian metastasis in most cases.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>With currently accepted protocols, the proposed guidelines are easy to apply and result in consistent site assignment in non\u2010uterine HGSC<\/jats:styled-content>s. Most cases of non\u2010uterine HGSC<\/jats:styled-content> were considered to be primary FT<\/jats:styled-content> neoplasms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12651","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T09:47:58Z","timestamp":1421228878000},"page":"331-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Assessment of a new system for primary site assignment in high\u2010grade serous carcinoma of the fallopian tube, ovary, and peritoneum"],"prefix":"10.1111","volume":"67","author":[{"given":"Naveena","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Cellular Pathology Barts Health NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Blake","family":"Gilks","sequence":"additional","affiliation":[{"name":"Department of Pathology Vancouver General Hospital and University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafisa","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Histopathology St James's Hospital Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W Glenn","family":"McCluggage","sequence":"additional","affiliation":[{"name":"Department of Pathology Belfast Health and Social Care Trust Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.10.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821201)50:11<2438::AID-CNCR2820501132>3.0.CO;2-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199105000-00001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181758831"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200110000-00009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1000"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000180854.28831.77"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213335.40358.47"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.05.010"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31822ea955"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4814"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2630"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000353"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e3182a80ac8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908806"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.1.27"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12419"},{"key":"e_1_2_6_19_1","volume-title":"World Health Organization classification of tumours: tumours of the breast and female genital organs","author":"Lee KR","year":"2003"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000293"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181934390"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200404000-00002"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3182a142c2"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.04.021"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12651","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:56:41Z","timestamp":1696467401000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,31]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/his.12651"],"URL":"https:\/\/doi.org\/10.1111\/his.12651","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,31]]},"assertion":[{"value":"2014-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}