{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:04:27Z","timestamp":1789596267603,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T00:00:00Z","timestamp":1426550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Orchid","award":["ONAG1Q3R"],"award-info":[{"award-number":["ONAG1Q3R"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The handling and reporting of testicular tumours is difficult due to their rarity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A survey developed by the European Network of Uro\u2010Pathology (<jats:styled-content style=\"fixed-case\">ENUP<\/jats:styled-content>) and sent to its members and experts to assess the evaluation of testicular germ cell tumours. Twenty\u2010five experts and 225 <jats:styled-content style=\"fixed-case\">ENUP<\/jats:styled-content> members replied. Areas of disagreement included immaturity in teratomas, reported by 32% of experts but 68% of <jats:styled-content style=\"fixed-case\">ENUP<\/jats:styled-content>. Although the presence of rete testis invasion was reported widely, the distinction between pagetoid and stromal invasion was made by 96% of experts but only 63% of <jats:styled-content style=\"fixed-case\">ENUP<\/jats:styled-content>. Immunohistochemistry was used in more than 50% of cases by 68% of <jats:styled-content style=\"fixed-case\">ENUP<\/jats:styled-content> and 12% of experts. Staging revealed the greatest areas of disagreement. Invasion of the tunica vaginalis without vascular invasion was interpreted as T1 by 52% of experts and 67% of <jats:styled-content style=\"fixed-case\">ENUP<\/jats:styled-content>, but T2 by the remainder. Tumour invading the hilar adipose tissue adjacent to the epididymis without vascular invasion was interpreted as T1: 40% of experts, 43% of <jats:styled-content style=\"fixed-case\">ENUP<\/jats:styled-content>; T2: 36% of experts, 30% of <jats:styled-content style=\"fixed-case\">ENUP<\/jats:styled-content>; and T3: 24% of experts, 27% of <jats:styled-content style=\"fixed-case\">ENUP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is remarkable consensus in many areas of testicular pathology. Significant areas of disagreement included staging and reporting of histological types, both of which have the potential to impact on therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12657","type":"journal-article","created":{"date-parts":[[2015,1,25]],"date-time":"2015-01-25T12:30:22Z","timestamp":1422189022000},"page":"313-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Handling and reporting of orchidectomy specimens with testicular cancer: areas of consensus and variation among 25 experts and 225 European pathologists"],"prefix":"10.1111","volume":"67","author":[{"given":"Daniel M","family":"Berney","sequence":"first","affiliation":[{"name":"Barts Cancer Institute Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Algaba","sequence":"additional","affiliation":[{"name":"Fundacio Puigvert\u2010University Autonomous Barcelona 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