{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:15:52Z","timestamp":1781820952682,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Information on tumour border configuration (<jats:styled-content style=\"fixed-case\">TBC<\/jats:styled-content>) in colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>) is currently not included in most pathology reports, owing to lack of reproducibility and\/or established evaluation systems. The aim of this study was to investigate whether an alternative scoring system based on the percentage of the infiltrating component may represent a reliable method for assessing <jats:styled-content style=\"fixed-case\">TBC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Two hundred and fifteen <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>s with complete clinicopathological data were evaluated by two independent observers, both \u2018traditionally\u2019 by assigning the tumours into pushing\/infiltrating\/mixed categories, and alternatively by scoring the percentage of infiltrating margin. With the pushing\/infiltrating\/mixed pattern method, interobserver agreement (<jats:styled-content style=\"fixed-case\">IOA<\/jats:styled-content>) was moderate (\u03ba\u00a0=\u00a00.58), whereas with the percentage of infiltrating margins method, <jats:styled-content style=\"fixed-case\">IOA<\/jats:styled-content> was excellent (intraclass correlation coefficient of 0.86). A higher percentage of infiltrating margin correlated with adverse features such as higher grade (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0025), higher <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0007), <jats:styled-content style=\"fixed-case\">pN<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001) and <jats:styled-content style=\"fixed-case\">pM<\/jats:styled-content> classification (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0063), high\u2010grade tumour budding (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), lymphatic invasion (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), vascular invasion (<jats:italic>P<\/jats:italic>\u00a0= 0.0032), and shorter survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0008), and was significantly associated with an increased probability of lymph node metastasis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Information on <jats:styled-content style=\"fixed-case\">TBC<\/jats:styled-content> gives additional prognostic value to pathology reports on <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>. The novel proposed scoring system, by using the percentage of infiltrating margin, outperforms the \u2018traditional\u2019 way of reporting <jats:styled-content style=\"fixed-case\">TBC<\/jats:styled-content>. Additionally, it is reproducible and simple to apply, and can therefore be easily integrated into daily diagnostic practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12665","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T11:45:09Z","timestamp":1423050309000},"page":"464-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Tumour border configuration in colorectal cancer: proposal for an alternative scoring system based on the percentage of infiltrating margin"],"prefix":"10.1111","volume":"67","author":[{"given":"Eva","family":"Karamitopoulou","sequence":"first","affiliation":[{"name":"Institute of Pathology Clinical Pathology Division University of Bern Bern Switzerland"},{"name":"Translational Research Unit University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inti","family":"Zlobec","sequence":"additional","affiliation":[{"name":"Translational Research Unit University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor Hendrik","family":"Koelzer","sequence":"additional","affiliation":[{"name":"Institute of Pathology Clinical Pathology Division University of Bern Bern Switzerland"},{"name":"Translational Research Unit University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Langer","sequence":"additional","affiliation":[{"name":"Institute of Pathology Clinical Pathology Division University of Bern Bern Switzerland"},{"name":"Translational Research Unit University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Dawson","sequence":"additional","affiliation":[{"name":"Institute of Pathology Clinical Pathology Division University of Bern Bern Switzerland"},{"name":"Translational Research Unit University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Lugli","sequence":"additional","affiliation":[{"name":"Institute of Pathology Clinical Pathology Division University of Bern Bern Switzerland"},{"name":"Translational Research Unit University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"UpToDate","author":"Compton C","year":"2014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2174-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24450"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0048"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016908"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1739::AID-CNCR30>3.0.CO;2-T"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-0979-PFICC"},{"key":"e_1_2_7_9_1","first-page":"516","article-title":"Should adjuvant chemotherapy become standard treatment for patients with stage II colon cancer? 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