{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:59:40Z","timestamp":1787169580905,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"\n Aims<\/jats:title>\n \n GATA<\/jats:styled-content>\n 3 is a zinc\u2010finger transcription factor that is important for trophoblast differentiation.\n GATA<\/jats:styled-content>\n 3 is sensitive for urothelial and breast carcinomas, but the specificity is low. The aim of this study was to investigate the expression of\n GATA<\/jats:styled-content>\n 3 in trophoblast\u2010related tissues and neoplasia.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n GATA<\/jats:styled-content>\n 3 immunohistochemistry was performed on 33 placentas, one atypical placental site nodule, 25 hydatidiform moles (\n HM<\/jats:styled-content>\n s), and 13 gestational trophoblastic tumours (\n GTT<\/jats:styled-content>\n s). One hundred and sixty endometrial adenocarcinomas were also stained. Western blotting was performed on trophoblastic cell lines and compared to other cancer cell lines. Immature placentas were characterized by strong, diffuse nuclear\n GATA<\/jats:styled-content>\n 3 staining. Mature placentas showed less expression with scattered positive cells in the villous cytotrophoblast.\n HM<\/jats:styled-content>\n s showed diffuse expression in cytotrophoblast and implantation site trophoblast, and heterogeneous expression in extravillous trophoblast. All\n GTT<\/jats:styled-content>\n s were positive for\n GATA<\/jats:styled-content>\n 3. All endometrial adenocarcinomas were\n GATA<\/jats:styled-content>\n 3\u2010negative. Western blotting demonstrated\n GATA<\/jats:styled-content>\n 3 in choriocarcinoma, whereas the placenta, and cervical and endometrial cancer cell lines, were negative.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n All trophoblast lineages were positive for\n GATA<\/jats:styled-content>\n 3. The extent of\n GATA<\/jats:styled-content>\n 3 expression varied between immature and mature placentas, suggesting a role in trophoblast maturation.\n GATA<\/jats:styled-content>\n 3 does not distinguish normal placenta,\n HM<\/jats:styled-content>\n s, or\n GTT<\/jats:styled-content>\n s. Nevertheless,\n GATA<\/jats:styled-content>\n 3 may help in distinguishing trophoblastic tumors from Mullerian epithelial malignancies and a subset of tumours of unknown origin.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/his.12681","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T10:11:35Z","timestamp":1425636695000},"page":"636-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["GATA<\/scp>\n 3 expression in gestational trophoblastic tissues and tumours"],"prefix":"10.1111","volume":"67","author":[{"given":"Jelena","family":"Mirkovic","sequence":"first","affiliation":[{"name":"Department of Pathology Women's and Perinatal Pathology Division Brigham and Women's Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Elias","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"},{"name":"Division of Gynecologic Oncology Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny","family":"Drapkin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana Farber Cancer Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine A","family":"Barletta","sequence":"additional","affiliation":[{"name":"Department of Pathology Women's and Perinatal Pathology Division Brigham and Women's Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Quade","sequence":"additional","affiliation":[{"name":"Department of Pathology Women's and Perinatal Pathology Division Brigham and Women's Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Pathology Women's and Perinatal Pathology Division Brigham and Women's Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21943"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.11.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.016840"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.038828"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1242\/dev.124.4.907","article-title":"GATA\u20102 and GATA\u20103 regulate trophoblast\u2010specific gene expression in\u00a0vivo","volume":"124","author":"Ma GT","year":"1997","journal-title":"Development"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP5UAFMSA9ZQBZ"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.09.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.11.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2014.12.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318260cde7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182a0218f"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000471"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000315"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90296-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90095-3"},{"key":"e_1_2_8_17_1","first-page":"87","article-title":"Histologic classification and staging of gestational trophoblastic disease","volume":"143","author":"Horn LC","year":"1997","journal-title":"Gen. 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