{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T13:10:59Z","timestamp":1726233059372},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Hairy cell leukaemia (<jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content>) is an indolent B\u2010cell neoplasm that primarily involves the peripheral blood, bone marrow, and spleen. Rarely, patients with <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> present with a lymphoma\u2010like clinicopathological picture mimicking other types of low\u2010grade B\u2010cell lymphoma. Distinguishing <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> from other types of lymphoma is essential, given the different treatments and prognoses. We report two cases of the lymphomatous variant of <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> to draw attention to this unusual presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Two cases of <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> presented initially as salivary gland and soft tissue masses. Morphologically, the neoplastic cells showed a typical fried\u2010egg or monocytoid appearance with reniform nuclei, and were positive for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11c, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>103, annexin A1, and cyclin D1. Both cases were positive for the <jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic> V600E mutation, as shown by pyrosequencing and mutation\u2010specific immunohistochemistry. The diagnosis was challenging in both patients, and one patient experienced 5\u00a0years of disease relapse and progression after treatment with multiple lymphoma\u2010type regimens before the final diagnosis of <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> was established and complete remission was achieved following cladribine therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> can very rarely present as an extranodal mass. Being aware of this unusual presentation of <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> is essential to avoid diagnostic confusion with other types of low\u2010grade B\u2010cell lymphoma and to facilitate appropriate therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12694","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T17:43:51Z","timestamp":1427219031000},"page":"740-745","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lymphomatous variant of hairy cell leukaemia: a distinctive presentation mimicking low\u2010grade B\u2010cell lymphoma"],"prefix":"10.1111","volume":"67","author":[{"given":"Hui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Pathology Xuzhou Medical College Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng Cameron","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Muzzafar","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,4]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"188","volume-title":"World Health Organization classification of tumors of hematopoietic and lymphoid tissues","author":"Foucar K","year":"2008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014209"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.1023"},{"key":"e_1_2_8_5_1","first-page":"266","article-title":"Absence of surface CD27 distinguishes hairy cell leukemia from other leukemic B\u2010cell malignancies","volume":"90","author":"Forconi F","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_8_6_1","first-page":"290","article-title":"Localized bone disease as a presentation of hairy cell leukemia","volume":"6","author":"Karmali R","year":"2008","journal-title":"Clin. 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