{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:02:11Z","timestamp":1787886131582,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Classic histopathological features of molluscum contagiosum (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>) include a crateriform, acanthotic epidermis containing intracytoplasmic molluscum bodies (<jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>s). In our experience, a subset of cases lack these features on initial haematoxylin and eosin\u2010stained sections. We aimed to describe the histopathological features of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> other than those classically described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Sixty\u2010seven biopsies diagnosed as <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> from January 2011 to October 2012 were retrospectively reviewed. Keratinocytes peripheral to the diagnostic cells with <jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>s had prominent nucleoli (67; 100%), amphophilic cytoplasm (54; 81%), and in many instances clear cytoplasmic vacuolization (38; 57%). Stroma surrounding <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> lesions showed fibroedematous to fibromyxoid changes in many cases (36; 54%), with a subset (13; 19%) showing abundant dermal mucin. In eight of 67 cases (12%), initial sections did not possess <jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>s or crateriform epidermis of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>. In these cases, initial sections revealed only the epithelial and\/or perilesional stromal changes described above. Additional sections contained <jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>s in all of these cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Perilesional fibroedematous to fibromyxoid stroma and keratinocyte changes, including prominent nucleoli and amphophilic cytoplasm with clear vacuolization, are common in <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>. Recognizing these features may prove helpful in reaching the diagnosis of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> in cases lacking classic histopathological features on initial sections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12716","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T15:03:26Z","timestamp":1429283006000},"page":"836-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Histopathological features of molluscum contagiosum other than molluscum bodies"],"prefix":"10.1111","volume":"67","author":[{"given":"Martin K","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P","family":"Arps","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conroy","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L","family":"Hocker","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R","family":"Fullen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"},{"name":"Department of Dermatology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,4]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"2905","volume-title":"Fields virology","author":"Moss B","year":"2007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70109-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.109302"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01448.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1001\/archderm.1968.01610140039008","article-title":"Molluscum contagiosum of the adult: probable venereal transmission","volume":"98","author":"Lynch PJ","year":"1968","journal-title":"Arch. Dermatol."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200104000-00003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2013.33380"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2004.00060.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03836.x"},{"key":"e_1_2_8_11_1","first-page":"44","article-title":"Eruptive xanthomas as a cutaneous manifestation of hypertriglyceridemia: a case report","volume":"4","author":"Digby M","year":"2011","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2012.01771.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00952.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1177\/014556130308200808","article-title":"Molluscum contagiosum","volume":"82","author":"Nelson BL","year":"2003","journal-title":"Ear Nose Throat J."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.110726"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(76)80006-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00677.x"},{"key":"e_1_2_8_18_1","first-page":"609","volume-title":"Weedon's skin pathology","author":"Weedon D","year":"2010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01322.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199810000-00019"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199904000-00013"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3180576ed9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04642.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03483.x"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12716","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:41:01Z","timestamp":1696340461000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,4]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/his.12716"],"URL":"https:\/\/doi.org\/10.1111\/his.12716","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,4]]},"assertion":[{"value":"2015-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}