{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:55:54Z","timestamp":1784919354759,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Histological features of chronic active ileitis in the small intestine neighbouring a Meckel's diverticulum raise the possibility of concurrent Crohn's disease. Several studies have reported a significant association between Meckel's diverticulum and Crohn's disease, whereas some case reports have proposed that the ileitis is attributable to acid\u2010secreting gastric heterotopia. The aim of this study was to evaluate the incidence, histomorphology and clinical follow\u2010up of Meckel's diverticulum\u2010associated ileitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Medical records and slides from 48 consecutive surgical resections performed for Meckel's diverticulum were reviewed. Nine of 48 adults had significant inflammatory changes in the small intestine neighbouring the diverticulum. Two were transmural ulcers attributable to ingestion of a sharp object. Two patients had established Crohn's disease, both with long segments (&gt;95\u00a0mm) of transmural inflammation located &gt;100\u00a0mm from the diverticulum. The remaining five patients had inflammatory changes (ulceration, pseudopyloric metaplasia, submucosal fibrosis, and muscularis mucosa hyperplasia) confined to a short segment (&lt;20\u00a0mm) of mucosa\/submucosa within 50\u201360\u00a0mm of the diverticulum. Two had gastric heterotopia in the diverticulum. None of these five patients used non\u2010steroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s). On follow\u2010up, none had symptoms, imaging or pathology suggestive of Crohn's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ileitis affecting a short segment of mucosa and submucosa in the small intestine near a Meckel's diverticulum is relatively common, and is not necessarily related to Crohn's disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12717","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T15:03:40Z","timestamp":1429283020000},"page":"783-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ileitis associated with Meckel's diverticulum"],"prefix":"10.1111","volume":"67","author":[{"given":"Claire M","family":"Hamilton","sequence":"first","affiliation":[{"name":"Division of Anatomical Pathology Queen Elizabeth II Health Sciences Centre and Dalhousie University Halifax NS Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Arnason","sequence":"additional","affiliation":[{"name":"Division of Anatomical Pathology Queen Elizabeth II Health Sciences Centre and Dalhousie University Halifax NS Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1931.01940150043003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00295917"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-0838-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896909331995"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.6.788"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01889027"},{"key":"e_1_2_8_8_1","first-page":"1173","article-title":"Meckel's diverticulum: a report of ninety\u2010three cases","volume":"21","author":"Baker AL","year":"1955","journal-title":"Am. 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Gastroenterol."},{"key":"e_1_2_8_15_1","first-page":"411","article-title":"Perforation of Meckel's diverticulum by foreign body, a rare complication","volume":"108","author":"Cotirlet A","year":"2013","journal-title":"Chirurgia (Bucur)"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102012\u2010008226"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0016-5085(58)80146-8","article-title":"Regional enteritis associated with Meckel's diverticulum; a report of five cases","volume":"34","author":"Ekman CN","year":"1958","journal-title":"Gastroenterology"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(75)80107-9"},{"key":"e_1_2_8_19_1","first-page":"18","article-title":"The pathological diagnosis and differential diagnosis of Crohn's disease","volume":"37","author":"Tanaka M","year":"1990","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_20_1","first-page":"291","article-title":"Meckel's diverticulum. An unusual case with ileal stricture","volume":"76","author":"Traube M","year":"1981","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.41.5.516"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1309\/7DDT5TDVB5C6BNHV"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12717","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:40:25Z","timestamp":1696340425000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,26]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/his.12717"],"URL":"https:\/\/doi.org\/10.1111\/his.12717","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,26]]},"assertion":[{"value":"2015-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}