{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:18:48Z","timestamp":1760242728013},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Most thymic carcinomas express the lymphocyte marker <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5 aberrantly. This study was performed to examine the role of the self\u2010reactive <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5 antigen in thymic carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We examined <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5 expression in thymic carcinoma in relation to the lymphoid stroma. All cases of thymic carcinoma examined expressed <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5. A number of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5<jats:sup>+<\/jats:sup> lymphocytes were also present in the stroma of thymic carcinoma. The <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5<jats:sup>+<\/jats:sup> tumour areas were predominantly in contact with the lymphoid stroma, and the expression level was significantly lower in tumour cells than lymphocytes. Although p53 and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>cl\u20102 expression levels were significantly higher in thymic carcinoma than normal thymic epithelial cells (<jats:styled-content style=\"fixed-case\">TEC<\/jats:styled-content>s), they did not differ between <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5<jats:sup>+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5<jats:sup>\u2212<\/jats:sup> areas. E\u2010cadherin expression in thymic carcinoma was comparable with that of normal <jats:styled-content style=\"fixed-case\">TEC<\/jats:styled-content>s, and it also did not differ between these areas. In contrast, both <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067 index and mitotic activity were significantly higher in thymic carcinoma than normal <jats:styled-content style=\"fixed-case\">TEC<\/jats:styled-content>s, and they were significantly higher in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5<jats:sup>+<\/jats:sup> than <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5<jats:sup>\u2212<\/jats:sup> areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5 may be induced by interaction with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5<jats:sup>+<\/jats:sup> lymphoid stroma, and may be related to tumour proliferation. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5 induction may also be a significant and\/or specific effect of the tumour microenvironment of the thymus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12742","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T14:48:47Z","timestamp":1432738127000},"page":"450-455","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The role of <scp>CD<\/scp>5 expression in thymic carcinoma: possible mechanism for interaction with <scp>CD<\/scp>5<sup>+<\/sup> lymphoid stroma (microenvironment)"],"prefix":"10.1111","volume":"68","author":[{"given":"Naoki","family":"Hosaka","sequence":"first","affiliation":[{"name":"Department of Pathology Kori Hospital\u2010Kansai Medical University Osaka Japan"},{"name":"Department of Clinical Sciences and Laboratory Medicine Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisato","family":"Ohe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hirakata Hospital\u2010Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Miyasaka","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hirakata Hospital\u2010Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yorika","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hirakata Hospital\u2010Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Sakaida","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hirakata Hospital\u2010Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hirakata Hospital\u2010Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihito","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Hirakata Hospital\u2010Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Ikehara","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Disorders Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Airo","family":"Tsubura","sequence":"additional","affiliation":[{"name":"Department of Pathology II Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakuo","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Laboratory Medicine Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-3123-9.50015-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4161\/cam.4.3.11789"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.03.001"},{"key":"e_1_2_7_5_1","first-page":"145","volume-title":"Tumours of the lung, pleura, thymus and heart. 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