{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:08:40Z","timestamp":1763726920014},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We hypothesized that asbestos exposure increases the incidence of macroscopically visible and histologically confirmed usual interstitial pneumonia (histological UIP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We retrospectively examined 1718 cases (1202 males; mean age 66.7\u00a0years) who underwent lobectomy for resection of pleuropulmonary tumours. Objective markers for asbestos exposure included: the presence of malignant pleural mesothelioma, the presence of pleural plaques (PPs) and asbestos bodies in the histological specimen. Risk factors for histological UIP were examined. Two separate groups were studied: 183 with asbestos exposure, and 239 with histological UIP. The 183 cases with asbestos exposure had higher rates of positive occupational history and histological UIP (31%) than the remaining 1535. Among the asbestos\u2010exposed group, small numbers of asbestos bodies were found in histological specimens of 21 cases of histological UIP. PPs and asbestos bodies were more frequent in the 239 patients with histological UIP than in the remaining 1479 UIP\u2010negative patients. Multivariate analysis showed that asbestos exposure, especially positivity for asbestos bodies, that does not meet the current criteria for asbestosis increases the risk of histological UIP (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Asbestos exposure causes asbestosis and increases the incidence of histological UIP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12751","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T13:43:46Z","timestamp":1433425426000},"page":"339-346","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Asbestos exposure increases the incidence of histologically confirmed usual interstitial pneumonia"],"prefix":"10.1111","volume":"68","author":[{"given":"Yoshinori","family":"Kawabata","sequence":"first","affiliation":[{"name":"Division of Diagnostic Pathology Saitama Prefectural Cardiovascular and Respiratory Centre Kumagaya city Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Saitama Prefectural Cardiovascular and Respiratory Centre Kumagaya city Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eishin","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Saitama Prefectural Cardiovascular and Respiratory Centre Kumagaya city Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Saitama Prefectural Cardiovascular and Respiratory Centre Kumagaya city Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Kanauchi","sequence":"additional","affiliation":[{"name":"Department of Radiology Saitama Prefectural Cardiovascular and Respiratory Centre Kumagaya city Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Kurashima","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Saitama Prefectural Cardiovascular and Respiratory Centre Kumagaya city Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Saitama Prefectural Cardiovascular and Respiratory Centre Kumagaya city Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.07.005"},{"key":"e_1_2_10_3_1","unstructured":"Act on Asbestos Health Damage Relief (Act No. 4 of 2006) Ministry of the Environment Japan."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.3_Pt_1.689"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2482\/haigan.48.254"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.226"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/134.3.462"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-9351(87)80084-1"},{"key":"e_1_2_10_11_1","first-page":"37","article-title":"Numbers and types of asbestos fibers in subjects with pleural plaques","volume":"109","author":"Warnock ML","year":"1982","journal-title":"Am. 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