{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T12:45:48Z","timestamp":1776170748670,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:00:00Z","timestamp":1438041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Pleomorphic adenoma (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) of the breast is a rare tumour seen usually in postmenopausal women. Although <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> of the salivary glands (<jats:styled-content style=\"fixed-case\">SG<\/jats:styled-content>) is recognized to be a benign tumour, the nature and biology of similar tumours seen in the breast remains to be defined. The aim of this study was to describe <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> of the breast that was reported on core biopsy as an invasive matrix\u2010producing metaplastic breast carcinoma (<jats:styled-content style=\"fixed-case\">MBC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A core biopsy from a clinically malignant retroareolar mass showed mildly atypical polygonal cells with surrounding myxoid stroma. Immunohistochemistry showed expression of basal and luminal cytokeratins, but oestrogen receptor, human epidermal growth factor receptor 2 (<jats:styled-content style=\"fixed-case\">HER<\/jats:styled-content>2) and myoepithelial markers were negative. The excision specimen showed similar features, but in addition the stroma showed cartilage and bone. Also it was clear that the lesion was circumscribed and merged with a sclerosed papillary lesion consistent with what has been described as mammary <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This lesion shows an overlap of morphology and immunophenotype with <jats:styled-content style=\"fixed-case\">SG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> and with <jats:styled-content style=\"fixed-case\">MBC<\/jats:styled-content>. The majority of mammary <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>s have a benign behaviour, but local recurrence and development of carcinoma occur. We propose a new terminology of pleomorphic adenoma\u2010like tumour of the breast to reflect the uncertain nature of these tumours and help guide management decisions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12757","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T14:50:23Z","timestamp":1434725423000},"page":"405-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Pleomorphic adenoma\u2010like tumour of the breast"],"prefix":"10.1111","volume":"68","author":[{"given":"Emad A","family":"Rakha","sequence":"first","affiliation":[{"name":"Department of Histopathology and Division of Cancer and Stem Cells School of Medicine The University of Nottingham and Nottingham University Hospitals NHS Trust Nottingham City Hospital Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A","family":"Aleskandarany","sequence":"additional","affiliation":[{"name":"Department of Histopathology and Division of Cancer and Stem Cells School of Medicine The University of Nottingham and Nottingham University Hospitals NHS Trust Nottingham City Hospital Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehab M","family":"Samaka","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Menoufia University Shebin ElKom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Hodi","sequence":"additional","affiliation":[{"name":"Department of Histopathology and Division of Cancer and Stem Cells School of Medicine The University of Nottingham and Nottingham University Hospitals NHS Trust Nottingham City Hospital Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H S","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Histopathology and Division of Cancer and Stem Cells School of Medicine The University of Nottingham and Nottingham University Hospitals NHS Trust Nottingham City Hospital Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian O","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Histopathology and Division of Cancer and Stem Cells School of Medicine The University of Nottingham and Nottingham University Hospitals NHS Trust Nottingham City Hospital Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)81190-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/387183"},{"key":"e_1_2_5_4_1","first-page":"427","article-title":"Pleomorphic adenoma of the breast initially misdiagnosed as metaplastic carcinoma in preoperative stereotactic biopsy: a case report and review of the literature","volume":"32","author":"Djakovic A","year":"2011","journal-title":"Eur. 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