{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:09:38Z","timestamp":1790770178329,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:00:00Z","timestamp":1438041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National R&D Programme for Cancer Control, Ministry of Health & Welfare","award":["12202201-31204"],"award-info":[{"award-number":["12202201-31204"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to investigate MYC expression and chromosomal aberration in mantle cell lymphoma (MCL), and the clinical significance of these factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Sixty\u2010five patients with MCL, including 54 classic, nine blastoid and two pleomorphic variants, were enrolled. Expression of MYC, Ki67 and p53 was assessed by immunohistochemistry. <jats:italic>MYC<\/jats:italic> amplification or translocation was examined by fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridization. MYC expression was higher in blastoid\/pleomorphic MCL variants (mean, 19.0%) than in classic MCL (mean, 1.9%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Expression of p53 and Ki67 was also significantly higher in these variants. <jats:italic>MYC<\/jats:italic> amplification was found in two of 53 cases tested, both of which were blastoid variants with high MYC expression (29.7% and 20.4%). <jats:italic>MYC<\/jats:italic> translocation was found in two of 52 cases tested, both of which were pleomorphic variants with remarkably high MYC expression (68.5% and 71.0%). High MYC or p53 expression was significantly associated with shortened overall survival and progression\u2010free survival in univariable and multivariable analyses (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MYC overexpression is a negative predictor of MCL patient outcomes. <jats:italic>MYC<\/jats:italic> gene amplification or translocation might be related to the pathogenesis of MCL, particularly in blastoid\/pleomorphic variants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12760","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T17:49:27Z","timestamp":1434995367000},"page":"442-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["MYC overexpression correlates with <i>MYC<\/i> amplification or translocation, and is associated with poor prognosis in mantle cell lymphoma"],"prefix":"10.1111","volume":"68","author":[{"given":"Ji\u2010Young","family":"Choe","sequence":"first","affiliation":[{"name":"Department of Pathology Seoul National University Bundang Hospital Seongnam Korea"},{"name":"Department of Pathology College of Medicine Seoul National University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yun","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Bundang Hospital Seongnam Korea"},{"name":"Department of Pathology College of Medicine Seoul National University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Young","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine Seoul National University Seoul Korea"},{"name":"Department of Pathology Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooryung","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Centre Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Jin","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Centre Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Inha University Hospital Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Ho","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young A","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Boramae Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Jeong","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Kyung","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeongsin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul St Mary's Hospital The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine Seoul National University Seoul Korea"},{"name":"Department of Pathology Seoul National University Boramae Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,28]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"World Health Organization classification of tumours of haematopoietic and lymphoid tissue","author":"Swerdlow S","year":"2008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.733882"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2011.09.007"},{"key":"e_1_2_8_5_1","first-page":"155","article-title":"Double\u2010hit mantle cell lymphoma with MYC gene rearrangement or amplification: a report of four cases and review of the literature","volume":"6","author":"Setoodeh R","year":"2013","journal-title":"Int. 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