{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:09:53Z","timestamp":1789769393678,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Institute\/National Institutes of Health","award":["R01CA138688"],"award-info":[{"award-number":["R01CA138688"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["1RC1CA146299"],"award-info":[{"award-number":["1RC1CA146299"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["P50CA136411"],"award-info":[{"award-number":["P50CA136411"]}]},{"name":"National Cancer Institute\/National Institutes of Health","award":["P50CA142509"],"award-info":[{"award-number":["P50CA142509"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Crystal\u2010storing histiocytosis (<jats:styled-content style=\"fixed-case\">CSH<\/jats:styled-content>) is a rare lesion composed of histiocytes with abnormal intralysosomal accumulation of immunoglobulin (Ig) as crystals, reported in patients with plasmacytic\/lymphoplasmacytic neoplasms. The aims of this study were to report the clinicopathological features of 13 patients with <jats:styled-content style=\"fixed-case\">CSH<\/jats:styled-content>, and to describe the proteomic composition of the crystals in three cases analysed by mass spectrometry (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>There were seven men and six women, with a median age of 60\u00a0years (range, 33\u201379\u00a0years). <jats:styled-content style=\"fixed-case\">CSH<\/jats:styled-content> was generalized in one patient (8%) and localized in 12 (92%) patients, involving various sites. <jats:styled-content style=\"fixed-case\">CSH<\/jats:styled-content> was associated with a low\u2010grade B\u2010cell lymphoma with plasmacytoid differentiation or a plasma cell neoplasm in all cases. In 10 (77%) cases, <jats:styled-content style=\"fixed-case\">CSH<\/jats:styled-content> represented &gt;50% of the neoplastic infiltrate. According to immunohistochemical studies, histiocytes were positive for monotypic kappa in 5 (50%) cases, and for monotypic lambda in 4 (40%) cases; in 1 (10%) case, the results were equivocal. <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> analysis of the histiocyte contents in all three tested cases showed a predominance of variable\u2010region fragments of Ig light and\/or heavy chains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CSH<\/jats:styled-content> is frequently associated with an underlying lymphoplasmacytic neoplasm. <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> findings suggest that Ig alterations and\/or possibly defects in the ability of histiocytes to process Ig play a role in pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12768","type":"journal-article","created":{"date-parts":[[2015,6,28]],"date-time":"2015-06-28T07:09:24Z","timestamp":1435475364000},"page":"482-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Crystal\u2010storing histiocytosis: a clinicopathological study of 13 cases"],"prefix":"10.1111","volume":"68","author":[{"given":"Rashmi","family":"Kanagal\u2010Shamanna","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun Y","family":"Xu\u2010Monette","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto N","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehui","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajyalakshmi","family":"Luthra","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P","family":"O'Malley","sequence":"additional","affiliation":[{"name":"Clarient Pathology Laboratory Aliso Viejo CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E","family":"Bueso\u2010Ramos","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Z","family":"Orlowski","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken H","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-011-0326-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31827b1618"},{"key":"e_1_2_8_4_1","first-page":"920","article-title":"Solitary crystal\u2010storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia","volume":"122","author":"Bosman C","year":"1998","journal-title":"Arch. Pathol. Lab. 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