{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:27:30Z","timestamp":1783121250747,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T00:00:00Z","timestamp":1440028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Baylor Oral Health Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To immunohistochemically evaluate the cytokeratin (<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>) pattern of expression in localized juvenile spongiotic gingival hyperplasia (<jats:styled-content style=\"fixed-case\">LJSGH<\/jats:styled-content>) as compared with the gingival epithelium (<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Ten cases of <jats:styled-content style=\"fixed-case\">LJSGH<\/jats:styled-content> were semiquantitatively evaluated for the immunohistochemical pattern of <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>1\/10, <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>4, <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>8\/18, and <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>19. <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content> controls were taken from 10 cases of reactive gingival fibroepithelial hyperplasia. <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>s showed mean positivity rates of 80% for both <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>1\/10 and <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>4, and 5% for both <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>8\/18 and <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>19. <jats:styled-content style=\"fixed-case\">LJSGH<\/jats:styled-content>s showed mean positivity rates of 65% for <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>19, 60% for <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>8\/18, 30% for <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>4, and 5% for <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>1\/10. The differences between <jats:styled-content style=\"fixed-case\">LJSGH<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>s were statistically significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">LJSGH<\/jats:styled-content> pattern of <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content> expression is reminiscent of the profile described in the literature for the junctional epithelium (<jats:styled-content style=\"fixed-case\">JE<\/jats:styled-content>). Possibly, <jats:styled-content style=\"fixed-case\">JE<\/jats:styled-content> exteriorized from the gingival sulcus would be more prone to irritation from a variety of sources, resulting in inflammation and hyperplasia, with the subsequent development of <jats:styled-content style=\"fixed-case\">LJSGH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12774","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T15:28:26Z","timestamp":1436282906000},"page":"549-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Localized juvenile spongiotic gingival hyperplasia possibly originates from the junctional gingival epithelium\u2014an immunohistochemical study"],"prefix":"10.1111","volume":"68","author":[{"given":"Irit","family":"Allon","sequence":"first","affiliation":[{"name":"Department of Oral Pathology &amp; Oral Medicine School of Dental Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaila M","family":"Lammert","sequence":"additional","affiliation":[{"name":"Baylor College of Dentistry Texas A&amp;M University Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Iwase","sequence":"additional","affiliation":[{"name":"Baylor College of Dentistry Texas A&amp;M University Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Spears","sequence":"additional","affiliation":[{"name":"Baylor College of Dentistry Texas A&amp;M University Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M","family":"Wright","sequence":"additional","affiliation":[{"name":"Baylor College of Dentistry Texas A&amp;M University Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Naidu","sequence":"additional","affiliation":[{"name":"Baylor College of Dentistry Texas A&amp;M University Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060502"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.04.024"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12214"},{"key":"e_1_2_6_5_1","first-page":"360","article-title":"Localized juvenile spongiotic gingival hyperplasia: a report of 3 cases","volume":"35","author":"Solomon LW","year":"2013","journal-title":"Pediatr. 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