{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:00:50Z","timestamp":1773680450774,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To report a case of paediatric malignant peritoneal mesothelioma (<jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content>) with evidence of anaplastic lymphoma kinase (<jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>) translocation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We describe a 10\u2010year\u2010old girl who presented with abdominal pain and progressive abdominal distension. She had no history of asbestos exposure. Histopathological, immunohistochemical and ultrastructural analyses were performed and\u00a0showed a biphasic malignant mesothelioma. In addition, we also studied on a selected set of immunomarkers which may be the potential therapeutic molecular targets including <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>, c\u2010kit (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>117), epidermal growth factor receptor (<jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content>) and human epidermal growth factor 2 (<jats:styled-content style=\"fixed-case\">HER<\/jats:styled-content>2)\/<jats:italic>neu<\/jats:italic>, as well as corresponding molecular analysis. Consequently, we identified <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content> expression by immunohistochemistry, together with evidence of <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content> translocation by fluorescent <jats:italic>in\u2010situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Paediatric <jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content> is associated with <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content> translocation in our case. The results may open up a new avenue for the study of molecular genesis of paediatric malignant mesothelioma in the future and help to determine whether patients <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>s with <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content> translocation would benefit from <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content> inhibitor treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12779","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T18:08:54Z","timestamp":1436897334000},"page":"603-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Anaplastic lymphoma kinase (<scp>ALK<\/scp>) translocation in paediatric malignant peritoneal mesothelioma: a case report of novel <scp>ALK<\/scp>\u2010related tumour spectrum"],"prefix":"10.1111","volume":"68","author":[{"given":"Kongsak","family":"Loharamtaweethong","sequence":"first","affiliation":[{"name":"Department of Anatomical Pathology Faculty of Medicine Vajira Hospital Navamindradhiraj University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Napaporn","family":"Puripat","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Faculty of Medicine Vajira Hospital Navamindradhiraj University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadda","family":"Aoonjai","sequence":"additional","affiliation":[{"name":"Department of Medical Services Electron Microscopy Laboratory Institute of Pathology Ministry of Public Health Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apisada","family":"Sutepvarnon","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Faculty of Medicine Vajira Hospital Navamindradhiraj University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanyoot","family":"Bandidwattanawong","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Faculty of Medicine Vajira Hospital Navamindradhiraj University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200109000-00018"},{"key":"e_1_2_7_3_1","first-page":"571","article-title":"Paediatric mesothelioma: is there the such a disease?","volume":"97","author":"Kashanskiy SV","year":"2010","journal-title":"Bull. 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