{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:17:26Z","timestamp":1787800646225,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We report the morphological spectrum of nine cystic clear cell papillary renal cell carcinomas (<jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Mean tumour size was 2.1\u00a0cm and the stage was <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>1a in all cases. The original diagnosis was multilocular clear cell cystic renal neoplasm of low malignant potential (<jats:styled-content style=\"fixed-case\">MCCN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LMP<\/jats:styled-content>) in five and <jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> in four patients. All examples were composed of variably sized cysts lined by one layer of clear cells. Two tumours were exclusively cystic, seven showed tubular formation in the septae and five in which the tubular growth was compact and pseudo\u2010solid. Two tumours had foci of nests and single cells showing similarities to the cellular areas of <jats:styled-content style=\"fixed-case\">MCCN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LMP<\/jats:styled-content>. The tubular\/pseudo\u2010solid\/nested\/single\u2010cells foci formed microscopic nodules with a mean size of 1.8\u00a0mm. Three tumours had intracystic micropapillary formation. Cells were of International Society of Urological Pathology (<jats:styled-content style=\"fixed-case\">ISUP<\/jats:styled-content>) grades 1\u20132\/4. In all cases, the neoplastic nuclei were aligned away from the basement membranes at least focally. Tumours were positive for paired box gene 8 (<jats:styled-content style=\"fixed-case\">PAX<\/jats:styled-content>8), carbonic anhydrase <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CAIX<\/jats:styled-content>), cytokeratin (<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>)7 and <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>34<jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>12 and negative for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cystic <jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> is a pattern that should be recognized, as it shows overlapping morphological features with both multilocular cyst and <jats:styled-content style=\"fixed-case\">MCCN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LMP<\/jats:styled-content>. This series raises the question of whether some reported <jats:styled-content style=\"fixed-case\">MCCN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LMP<\/jats:styled-content>s are actually cystic <jats:styled-content style=\"fixed-case\">CCP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12797","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T15:39:02Z","timestamp":1438961942000},"page":"666-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cystic clear cell papillary renal cell carcinoma: is it related to multilocular clear cell cystic neoplasm of low malignant potential?"],"prefix":"10.1111","volume":"68","author":[{"given":"Fadi","family":"Brimo","sequence":"first","affiliation":[{"name":"McGill University Health Center Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Atallah","sequence":"additional","affiliation":[{"name":"McGill University Health Center Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangyong","family":"Li","sequence":"additional","affiliation":[{"name":"Trillium Health Partners Mississauga ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Srigley","sequence":"additional","affiliation":[{"name":"Trillium Health Partners Mississauga ON Canada"},{"name":"McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)61903-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.10.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.11.035"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1309\/AH6FC77PYR2V6YAY","article-title":"Multilocular cystic renal cell carcinoma : a report of 45 cases of a kidney tumor of low malignant potential","volume":"125","author":"Suzigan S","year":"2006","journal-title":"Am. 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