{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:39:06Z","timestamp":1761709146095},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Hashimoto's thyroiditis was recently divided into IgG4\u2010plasma cell\u2010rich and IgG4\u2010plasma cell\u2010poor subtypes. The former, also known as IgG4 thyroiditis, is associated with clinical, serological, sonographic and morphological features that are distinctive from those of the non\u2010IgG4 subgroup. We describe an interesting case of IgG4\u2010positive mucosa\u2010associated lymphoid tissue (<jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>) lymphoma arising in a background of IgG4 thyroiditis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The thyroid gland showed typical features of IgG4 thyroiditis, including characteristic patterns of fibrosis. A dense lymphoplasmacytic infiltrate diffusely involved the entire gland without formation of a destructive tumour mass. Lymphoepithelial lesions were prominent. There were abundant IgG4\u2010positive plasma cells, with the IgG4\/IgG ratio exceeding 40%. The IgG4\u2010positive plasma cells were monotypic for kappa light chain, and there was monoclonal <jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic> rearrangement. Fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridization revealed <jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic> translocation without translocation of <jats:italic><jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic>,<jats:italic> bcl\u201010<\/jats:italic>, or <jats:italic><jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>1<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This represents the first case of IgG4\u2010producing <jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content> lymphoma associated with IgG4 thyroiditis. <jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic> translocation with an unknown partner gene was identified. We suggest the performance of serum and immunohistochemical investigations for IgG and IgG4 in all cases of Hashimoto's thyroiditis to diagnose IgG4 thyroiditis. In addition, clonality assays and light chain studies are useful to exclude a low\u2010grade lymphoma arising in this context.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12854","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T16:54:10Z","timestamp":1441212850000},"page":"931-937","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["IgG4\u2010positive extranodal marginal zone lymphoma arising in Hashimoto's thyroiditis: clinicopathological and cytogenetic features of a hitherto undescribed condition"],"prefix":"10.1111","volume":"68","author":[{"given":"Char\u2010Loo","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pathology National University Health System Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yew\u2010Kwang","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery National University Health System Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010Yong","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology Singapore General Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siok\u2010Bian","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Pathology National University of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.72"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.68"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02419.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.1.8156"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2012.12.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02771.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ11-0309"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.47.31"},{"key":"e_1_2_9_10_1","first-page":"214","volume-title":"World Health Organization classification of tumours of haematopoietic and lymphoid tissues","author":"Isaacson P","year":"2008"},{"key":"e_1_2_9_11_1","first-page":"140037","article-title":"IgG4\u2010related thyroiditis: a case report and review of literature","volume":"2014","author":"Abo Salook M","year":"2014","journal-title":"Endocrinol. Diabetes Metab. Case Rep."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000003283"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-011-0520-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1681"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2010.02524.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31816148ad"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2013.01.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12500"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.52.51"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-008-0170-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.206"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.106"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12854","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:27:14Z","timestamp":1696346834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,2]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/his.12854"],"URL":"https:\/\/doi.org\/10.1111\/his.12854","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,2]]},"assertion":[{"value":"2015-11-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}