{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:12:33Z","timestamp":1785683553150,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The p63 gene shares structural and functional homologies with the p53 family of transcriptional activators, but differs in exhibiting a consistent expression pattern in normal tissues. Although p63 is rarely mutated in malignancy studies of primary human tumours and cell lines suggest that p63 may promote tumour development. In non\u2010Hodgkin's nodal lymphoma, <jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content>p63 expression in follicular lymphoma (54%) and diffuse large B cell lymphoma (34%) has been described and correlated with the proliferative index. In this study, we analysed a series of primary cutaneous B cell lymphomas for immunohistochemical expression of p63.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Thirty cases of diffuse large B cell lymphoma leg type (pc<jats:styled-content style=\"fixed-case\">DLBCLL<\/jats:styled-content>) and 34 cases of follicle centre cell lymphoma (pc<jats:styled-content style=\"fixed-case\">FCCL<\/jats:styled-content>) were stained using a generic antibody to p63, and a subset of these with an antibody specific for delta\u2010Np63 isoform. The results indicate a significant difference between pc<jats:styled-content style=\"fixed-case\">DLBCLL<\/jats:styled-content> (21 of 30) and pc<jats:styled-content style=\"fixed-case\">FCCL<\/jats:styled-content> (four of 34) in p63 expression (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.000); expression correlated strongly with the proliferation rate as assessed by Ki\u201067 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.015). None of the p63<jats:sup>(+)<\/jats:sup> cases tested expressed the delta\u2010Np63 isoform, suggesting that expression is of the <jats:styled-content style=\"fixed-case\">TAp63<\/jats:styled-content> isoform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Functional studies are required to clarify the significance of p63 overexpression in primary cutaneous B cell lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12855","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T20:10:55Z","timestamp":1441224655000},"page":"11-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Immunocytochemical p63 expression discriminates between primary cutaneous follicle centre cell and diffuse large B cell lymphoma\u2010leg type, and is of the <scp>TA<\/scp>p63 isoform"],"prefix":"10.1111","volume":"69","author":[{"given":"Alistair","family":"Robson","sequence":"first","affiliation":[{"name":"St John's Institute of Dermatology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zena","family":"Shukur","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Ally","sequence":"additional","affiliation":[{"name":"Department of Dermatology Stanford University Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Kluk","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Health and Social Care Research Kings College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pincus","sequence":"additional","affiliation":[{"name":"Department of Pathology UCSF San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debjani","family":"Sahni","sequence":"additional","affiliation":[{"name":"Department of Dermatology Boston University Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Sundram","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Subtil","sequence":"additional","affiliation":[{"name":"Dermatopathology Department Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Karai","sequence":"additional","affiliation":[{"name":"Lake Diagnostics Florida Lake City FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Kempf","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schieke","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Coates","sequence":"additional","affiliation":[{"name":"Dundee Cancer Centre Ninewells Hospital and Medical School Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1231"},{"key":"e_1_2_7_3_1","first-page":"494","article-title":"p63 expression profiles in human normal and tumor tissues","volume":"8","author":"Como CJ","year":"2002","journal-title":"Clin. 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