{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:29:02Z","timestamp":1790857742620,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T00:00:00Z","timestamp":1445990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"\n Aims<\/jats:title>\n \n The correct identification of solid cell nests (\n SCN<\/jats:styled-content>\n s) is an important issue in thyroid pathology because of the spectrum of differential diagnoses of this type of lesion.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n Ten cases of 295 consecutive thyroidectomies showed the presence of\n SCN<\/jats:styled-content>\n s at histological examination. The identification of the exact\n SCN<\/jats:styled-content>\n type required the distinction of the cystic and solid pattern;\n SCN<\/jats:styled-content>\n s were usually composed of a mixture of main cells (\n MC<\/jats:styled-content>\n s) and C\u2010cells (\n CC<\/jats:styled-content>\n s). The immunohistochemical calcitonin stain identified\n CC<\/jats:styled-content>\n s easily, both inside\n SCN<\/jats:styled-content>\n s and dispersed in islets at the periphery. For the characterization of\n MC<\/jats:styled-content>\n s, we added the utility of p40 to p63. The use of thyroid transcription factor\u20101 (\n TTF<\/jats:styled-content>\n \u20101) helped in their identification, as\n MC<\/jats:styled-content>\n s did not react with this marker; the combination of\n TTF<\/jats:styled-content>\n \u20101 and p40 or p63\n IHC<\/jats:styled-content>\n stains was useful for the characterization of cystic\n SCN<\/jats:styled-content>\n s of both types 3 and 4. The negativity of mouse monoclonal mesothelioma antibody (\n HMBE<\/jats:styled-content>\n \u20101) and a very low proliferative index (\n MIB<\/jats:styled-content>\n \u20101) supported the diagnosis. [Correction added on 23 November 2015, after online publication:\n MIB<\/jats:styled-content>\n \u20101 was incorrectly defined, the expanded form was deleted.] We discourage the use of galectin\u20103 (Gal\u20103) and cytokeratin\u201019 (\n CK<\/jats:styled-content>\n \u201019), as they have an important overlap with papillary thyroid carcinoma. The complete absence of any B\u2010Raf proto\u2010oncogene, serine\/threonine kinase (\n BRAF<\/jats:styled-content>\n ) mutations is an additional fundamental finding.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n We reviewed the most relevant morphological and immunohistochemical features of\n SCN<\/jats:styled-content>\n s and have provided a genetic analysis of the\n BRAF<\/jats:styled-content>\n gene because of its expanding use in thyroid pathology.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/his.12858","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T10:59:57Z","timestamp":1441277997000},"page":"866-874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Solid cell nests of the thyroid gland: morphological, immunohistochemical and genetic features"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0062-1264","authenticated-orcid":false,"given":"Marco","family":"Manzoni","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery Section of Pathology University Milan Bicocca Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Roversi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Section of Genetics University Milan Bicocca Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camillo","family":"Di Bella","sequence":"additional","affiliation":[{"name":"Department of Pathology Desio Hospital Desio Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela I","family":"Pincelli","sequence":"additional","affiliation":[{"name":"Department of Endocrinology San Gerardo Hospital Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Cimino","sequence":"additional","affiliation":[{"name":"Department of Endocrinology San Gerardo Hospital Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Perotti","sequence":"additional","affiliation":[{"name":"Department of Endocrinology San Gerardo Hospital Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Garancini","sequence":"additional","affiliation":[{"name":"Department of Surgery University Milan Bicocca Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pagni","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Section of Pathology University Milan Bicocca Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01945893"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90302-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-009-9095-x"},{"key":"e_1_2_6_5_1","volume-title":"Diagnostic pathology and molecular genetics of the thyroid: a comprehensive guide for practicing thyroid pathology","author":"Nikiforov YE","year":"2012"},{"key":"e_1_2_6_6_1","unstructured":"Cancer Protocol Templates \u2013 College of American Pathologists [internet][cited 25 August 2015]. Available at:http:\/\/www.cap.org\/web\/home\/resources\/cancer-reporting-tools\/cancer-protocol-templates?_afrLoop=8864270637760#%40%3F_afrLoop%3D8864270637760%26_adf.ctrl-state%3D9oamh2d2w_43: Accessed 25 August 2015."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12085"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711550303"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-13"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-014-9323-x"},{"key":"e_1_2_6_11_1","first-page":"196","article-title":"Solid cell nests and thyroid pathologies. Retrospective study of 1,390 thyroids","volume":"20","author":"Martin V","year":"2000","journal-title":"Ann. 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