{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:02:21Z","timestamp":1788883341630,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T00:00:00Z","timestamp":1449187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    Although most breast spindle cell lesions (\n                    <jats:styled-content style=\"fixed-case\">BSCL<\/jats:styled-content>\n                    s) are rare, they constitute a wide spectrum of diseases, ranging from reactive processes to aggressive malignant tumours. Despite their varied histogenesis and behaviour, some lesions show an overlap of morphological features, making accurate diagnosis a challenging task, particularly in needle core biopsies. Clinical history and immunohistochemistry can help in making a correct diagnosis in morphologically challenging cases. To make an accurate diagnosis, it is important to maintain a wide differential diagnosis and be familiar with the diverse morphological appearances of these different entities.\n                    <jats:styled-content style=\"fixed-case\">BSCL<\/jats:styled-content>\n                    s can generally be classified into bland\u2010looking and malignant\u2010looking categories. In the former, the commonest diagnosis is scarring. However, it is important to distinguish low\u2010grade spindle cell metaplastic breast carcinoma from other benign entities, as the management is clearly different. In the malignant category, it is important to differentiate metaplastic carcinoma from other malignant primary and metastatic malignant spindle cell tumours of the breast, such as malignant phyllodes tumour, angiosarcoma, and melanoma. This review focuses on the classification and histological and molecular diagnosis of various\n                    <jats:styled-content style=\"fixed-case\">BSCL<\/jats:styled-content>\n                    s, with an emphasis on the diagnostic approach, including in core biopsies.\n                  <\/jats:p>","DOI":"10.1111\/his.12865","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T05:20:26Z","timestamp":1450761626000},"page":"33-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["An approach to the diagnosis of spindle cell lesions of the breast"],"prefix":"10.1111","volume":"68","author":[{"given":"Emad A","family":"Rakha","sequence":"first","affiliation":[{"name":"Department of Histopathology Nottingham University Hospitals NHS Trust and the University of Nottingham Nottingham City Hospital Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A","family":"Aleskandarany","sequence":"additional","affiliation":[{"name":"Department of Histopathology Nottingham University Hospitals NHS Trust and the University of Nottingham Nottingham City Hospital Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H S","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Histopathology Nottingham University Hospitals NHS Trust and the University of Nottingham Nottingham City Hospital Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian O","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Histopathology Nottingham University Hospitals NHS Trust and the University of Nottingham Nottingham City Hospital Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350774"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2011.02.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/51.5.610"},{"key":"e_1_2_7_5_1","volume-title":"Rosen's breast pathology","author":"Rosen PP","year":"2009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00612190"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840501)53:9<1908::AID-CNCR2820530917>3.0.CO;2-F"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2872"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880456"},{"issue":"1","key":"e_1_2_7_10_1","first-page":"S190","article-title":"Myoepithelial cells in pathology","volume":"7","author":"Balachander N","year":"2015","journal-title":"J. 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