{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:19:10Z","timestamp":1792621150857,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T00:00:00Z","timestamp":1449187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>E\u2010cadherin immunohistochemistry is used commonly in surgical pathology practice to help distinguish lobular carcinoma <jats:italic>in\u00a0situ<\/jats:italic> from ductal carcinoma <jats:italic>in\u00a0situ<\/jats:italic> and invasive lobular carcinoma from invasive ductal carcinoma in histologically problematic or indeterminate cases. However, the interpretation of E\u2010cadherin immunostains is not always straightforward. Failure to recognize the pitfalls and limitations of E\u2010cadherin immunostains can lead to an erroneous diagnosis which may result in inappropriate patient management, particularly for patients with <jats:italic>in\u2010situ<\/jats:italic> lesions. In this paper we review the uses and, particularly, the pitfalls in the interpretation of E\u2010cadherin immunostains in distinguishing lobular from ductal lesions of the breast.<\/jats:p>","DOI":"10.1111\/his.12869","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T10:20:26Z","timestamp":1450779626000},"page":"57-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["E\u2010cadherin immunohistochemistry in breast pathology: uses and pitfalls"],"prefix":"10.1111","volume":"68","author":[{"given":"Rita","family":"Canas\u2010Marques","sequence":"first","affiliation":[{"name":"Department of Pathology Champalimaud Foundation Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J","family":"Schnitt","sequence":"additional","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,4]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"78","volume-title":"WHO classification of tumours of the breast","author":"Lakhani SR","year":"2012"},{"key":"e_1_2_5_3_1","first-page":"40","volume-title":"WHO classification of tumours of the breast","author":"Lakhani SR","year":"2012"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdip.2003.11.003"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200607000-00002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800362"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182918a2b"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-015-0517-z"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-015-0580-5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-015-0519-x"},{"key":"e_1_2_5_11_1","first-page":"1919","article-title":"E\u2010cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain","volume":"13","author":"Berx G","year":"1996","journal-title":"Oncogene"},{"key":"e_1_2_5_12_1","first-page":"1731","article-title":"Differential loss of E\u2010cadherin expression in infiltrating ductal and lobular breast carcinomas","volume":"143","author":"Moll R","year":"1993","journal-title":"Am. 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