{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:56:37Z","timestamp":1791309397851,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Phosphaturic mesenchymal tumour (<jats:styled-content style=\"fixed-case\">PMT<\/jats:styled-content>) is a rare, recently described neoplastic entity. It is characterized by distinct histological features, which often occur together with oncogenic osteomalacia. Recently, a novel <jats:italic><jats:styled-content style=\"fixed-case\">FN<\/jats:styled-content>1\u2013<jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>1<\/jats:italic> gene fusion has been described in a subset of <jats:styled-content style=\"fixed-case\">PMT<\/jats:styled-content>s. The aim of this study is to characterise the clinicopathological features of two <jats:styled-content style=\"fixed-case\">PMT<\/jats:styled-content>s, with <jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>1 immunohistochemical and cytogenetic analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We present two contrasting cases of <jats:styled-content style=\"fixed-case\">PMT<\/jats:styled-content>, one occurring in the sinonasal region, and the other occurring in bone (proximal femur). In the former, local effects, including epistaxis and anosmia, dominated the clinical presentation, whereas the latter case presented with refractory bone pain, muscle weakness, and occult osteomalacia, the cause of which was only identified after 2\u00a0years. Both tumours showed characteristic histological features of <jats:styled-content style=\"fixed-case\">PMT<\/jats:styled-content>, including a monomorphic proliferation of round to ovoid cells, osteoclast\u2010like multinucleated giant cells, and areas of \u2018smudgy\u2019 basophilic calcifications. Chromogenic <jats:italic>in\u2010situ<\/jats:italic> hybridization showed fibroblast growth factor <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023 expression by the sinonasal tumour. By using immunohistochemistry, we also demonstrated, for the first time, <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content> receptor 1 (<jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>1) protein overexpression in this tumour, for which <jats:italic><jats:styled-content style=\"fixed-case\">FN<\/jats:styled-content>1\u2013<jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>1<\/jats:italic> gene fusion was not detected by fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate that up\u2010regulation of <jats:italic><jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>1<\/jats:italic> in phosphaturic mesenchymal tumours can occur via mechanisms other than <jats:italic><jats:styled-content style=\"fixed-case\">FN<\/jats:styled-content>1\u2013<jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>1<\/jats:italic> fusion, raising the possibility of <jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>1 overexpression being a potential common pathway with pathophysiological and therapeutic implications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12872","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T16:56:57Z","timestamp":1443200217000},"page":"925-930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["From epistaxis to bone pain\u2014report of two cases illustrating the clinicopathological spectrum of phosphaturic mesenchymal tumour with fibroblast growth factor receptor 1 immunohistochemical and cytogenetic analyses"],"prefix":"10.1111","volume":"68","author":[{"given":"Yingting","family":"Mok","sequence":"first","affiliation":[{"name":"Department of Pathology National University Health System Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen\u2010chieh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey Huey Yew","family":"Lum","sequence":"additional","affiliation":[{"name":"Department of Pathology National University Health System Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Petersson","sequence":"additional","affiliation":[{"name":"Department of Pathology National University Health System Singapore 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