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Distinction of benign phyllodes tumours from cellular fibroadenomas is fraught with difficulty, due to overlapping microscopic features. Similarly, separation of the malignant phyllodes tumour from spindle cell metaplastic carcinoma and primary breast sarcoma can be problematic. Phyllodes tumours are treated by surgical excision. However, there is no consensus on the definition of an appropriate surgical margin to ensure completeness of excision and reduction of recurrence risk. Interpretive subjectivity, overlapping histological diagnostic criteria, suboptimal correlation between histological classification and clinical behaviour and the lack of robust molecular predictors of outcome make further investigation of the pathogenesis of these fascinating tumours a matter of active research. This review consolidates the current understanding of their pathobiology and clinical behaviour, and includes proposals for a rational approach to the classification and management of phyllodes tumours.<\/jats:p>","DOI":"10.1111\/his.12876","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T05:20:26Z","timestamp":1450761626000},"page":"5-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":441,"title":["Phyllodes tumours of the breast: a consensus review"],"prefix":"10.1111","volume":"68","author":[{"given":"Benjamin Y","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pathology Singapore General Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geza","family":"Acs","sequence":"additional","affiliation":[{"name":"Women's Pathology Consultants Ruffolo Hooper &amp; Associates Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia K","family":"Apple","sequence":"additional","affiliation":[{"name":"Department of Pathology UCLA Medical Center Santa Monica CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Badve","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Internal Medicine Clarian Pathology Laboratory of Indiana University Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira J","family":"Bleiweiss","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edi","family":"Brogi","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 P","family":"Calvo","sequence":"additional","affiliation":[{"name":"Servicio de Anatom\u00eda Patol\u00f3gica Hospital Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Dabbs","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian O","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Histopathology Nottingham City Hospital NHS Trust Nottingham University Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Eusebi","sequence":"additional","affiliation":[{"name":"Sezione Anatomia e Istologia Patologica \u2018M. 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