{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:08:24Z","timestamp":1774476504199,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Chondrosarcoma is primarily a tumour of adulthood and old age. Some studies indicate that survival is worse in paediatric than in adult chondrosarcomas. In view of the rarity of paediatric chondrosarcoma, few large studies are currently available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We evaluated the clinical, radiological and pathological features of a single institution series of chondrosarcomas presenting in patients younger than 17\u00a0years between 1981 and 2014. Seventeen patients with central (10), peripheral (five) and periosteal (two) chondrosarcoma were retrieved. The patients received various treatments according to the dimension, stage and grading of the lesions. Only two tumours, treated with resection, recurred after the first diagnosis, at 11 and 108\u00a0months, respectively. All patients but one were alive without disease at the time of the last follow\u2010up (median: 148\u00a0months). The one patient who died of disease 27\u00a0months after diagnosis had a grade 2 central chondrosarcoma of the metacarpal bone. He was affected by Maffucci syndrome and developed multiple bone and lung metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chondrosarcoma in children is rare but does exist, and is not limited to the head and neck region. Our findings do not support the current view that chondrosarcomas are more aggressive in children than in adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12881","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T15:42:39Z","timestamp":1443282159000},"page":"1073-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Paediatric chondrosarcomas: a retrospective review of 17 cases"],"prefix":"10.1111","volume":"68","author":[{"given":"Marco","family":"Gambarotti","sequence":"first","affiliation":[{"name":"Department of Pathology Rizzoli Institute Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Righi","sequence":"additional","affiliation":[{"name":"Department of Pathology Rizzoli Institute Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Picci","sequence":"additional","affiliation":[{"name":"Department of Pathology Rizzoli Institute Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Bertoni","sequence":"additional","affiliation":[{"name":"Department of Pathology Rizzoli Institute Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Manfrini","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology Rizzoli Institute Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide M","family":"Donati","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology Rizzoli Institute Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo P","family":"Dei Tos","sequence":"additional","affiliation":[{"name":"Department of Pathology Rizzoli Institute Bologna Italy"},{"name":"Department of Pathology Treviso Regional Hospital Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Vanel","sequence":"additional","affiliation":[{"name":"Department of Pathology Rizzoli Institute Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"264","volume-title":"World Health Organization classification of tumours. 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