{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:34:36Z","timestamp":1790393676924,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T00:00:00Z","timestamp":1449532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Aims<\/jats:title>Large B cell lymphomas with MYC<\/jats:styled-content><\/jats:italic> and BCL<\/jats:styled-content>6<\/jats:italic>\/3q27 rearrangements, designated MYC<\/jats:styled-content>\/BCL<\/jats:styled-content>6 <\/jats:italic>DHL<\/jats:styled-content>, are uncommon. Our aim was to better characterize this group of tumours.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>We studied the clinicopathological features and outcome of 13 patients with MYC<\/jats:styled-content>\/BCL<\/jats:styled-content>6 <\/jats:italic>DHL<\/jats:styled-content> and compared this group to a group of 83 MYC<\/jats:styled-content>\/BCL<\/jats:styled-content>2 <\/jats:italic>DHL<\/jats:styled-content> patients. There were eight men and five women, with a median age of 63 years. Eleven tumours were classified as diffuse large B cell lymphomas (DLBCL<\/jats:styled-content>) and two were B cell lymphoma, unclassifiable, with features intermediate between DLBCL<\/jats:styled-content> and Burkitt lymphoma (BCLU<\/jats:styled-content>). Immunohistochemical analysis showed that these tumours were positive for BCL<\/jats:styled-content>6 (100%), BCL<\/jats:styled-content>2 (eight of 10; 80%) and CD<\/jats:styled-content>10 (eight of 10; 80%). Nine of 12 (75%) cases had a germinal centre B cell (GCB<\/jats:styled-content>) immunophenotype; in one case data were incomplete. All patients were treated with chemotherapy. The clinicopathological features of MYC<\/jats:styled-content>\/BCL<\/jats:styled-content>6 <\/jats:italic>DHL<\/jats:styled-content> were similar to MYC<\/jats:styled-content>\/BCL<\/jats:styled-content>2 <\/jats:italic>DHL<\/jats:styled-content>, except that MYC<\/jats:styled-content>\/BCL<\/jats:styled-content>6 <\/jats:italic>DHL<\/jats:styled-content> had a GCB<\/jats:styled-content> immunophenotype less often. Patients with MYC<\/jats:styled-content>\/BCL<\/jats:styled-content>6 <\/jats:italic>DHL<\/jats:styled-content> had a poor overall survival, similar to patients with MYC<\/jats:styled-content>\/BCL<\/jats:styled-content>2 <\/jats:italic>DHL<\/jats:styled-content> (P<\/jats:italic> = 0.32).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>MYC<\/jats:styled-content>\/BCL<\/jats:styled-content>6 <\/jats:italic>DHL<\/jats:styled-content> is an aggressive B cell lymphoma and patients often have an aggressive clinical course and poor prognosis, similar to patients with MYC<\/jats:styled-content>\/BCL<\/jats:styled-content>2 <\/jats:italic>DHL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12884","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T22:40:44Z","timestamp":1443739244000},"page":"1090-1098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["MYC<\/scp>\/BCL<\/scp>6<\/i> double\u2010hit lymphoma (DHL<\/scp>): a tumour associated with an aggressive clinical course and poor prognosis"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-0523","authenticated-orcid":false,"given":"Shaoying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center Nashville TN 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J","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergej N","family":"Konoplev","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E","family":"Bueso\u2010Ramos","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L 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