{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:33:09Z","timestamp":1790375589576,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Forkhead box protein 3\u2010positive (FoxP3<jats:sup>+<\/jats:sup>) T cell lymphoma, in the absence of human T cell lymphotrophic virus type 1 (<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101) infection, is rare and its clinicopathological characteristics still remain unclear. The aim of this study was to elucidate its characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We describe here 11 cases of peripheral T cell lymphoma not otherwise specified (<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>) and two cases of mycosis fingoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>) which were positive for FoxP3. The median age of the 11 <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content> cases was 65 years (range: 48\u201380 years), and all the patients were male. Eight patients (80%) showed stages <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> disease, and six (60%) were categorized as high\u2013intermediate\/high\u2010risk groups according to the International Prognostic Index. Two cases of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> were 57\u2010 and 59\u2010year\u2010old males. Both cases were categorized as stage <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>, according to International Society for Cutaneous Lymphomas\/European Organization of Research and Treatment of Cancer (<jats:styled-content style=\"fixed-case\">ISCL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>) classification. Immunohistochemically, all the cases were negative for cytotoxic molecule marker, and nine (75%) were \u03b1\u03b2 T cell type. Scattered Epstein\u2013Barr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>)\u2010infected cells were detected in four cases of <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>, implying the reactivation of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> caused by the immunodeficient status of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FoxP3<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content> constitute a minor phenotypical subtype with poor prognosis and <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> reactivation in some. Conversely, two cases of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> showed an indolent clinical course which was different from previously reported cutaneous T cell lymphoma (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>) cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12885","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T22:26:44Z","timestamp":1443738404000},"page":"1099-1108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["FoxP3\u2010positive T cell lymphoma arising in non\u2010HTLV1 carrier: clinicopathological analysis of 11 cases of PTCL\u2010NOS and 2 cases of mycosis fungoides"],"prefix":"10.1111","volume":"68","author":[{"given":"Akira","family":"Satou","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Nagano Prefectural Suzaka Hospital Suzaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Katsuya","sequence":"additional","affiliation":[{"name":"Division of Oncology, Hematology and Infectious Diseases Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ishitsuka","sequence":"additional","affiliation":[{"name":"Division of Oncology, Hematology and Infectious Diseases Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"},{"name":"Department of Pathology Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya 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