{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:57:12Z","timestamp":1753883832017},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007268","name":"Washington University in St. Louis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Subtle lesions of terminal hepatic venules (<jats:styled-content style=\"fixed-case\">THV<\/jats:styled-content>s) may be overlooked in liver biopsies from haematopoietic stem cell transplant (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) receipients when graft\u2010versus\u2010host disease is the clinical concern. The aim of this study was to evaluate the frequency of <jats:styled-content style=\"fixed-case\">THV<\/jats:styled-content> injury resembling sinusoidal obstruction syndrome (<jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Sixty\u2010three consecutive biopsies from allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> recipients were scored for injured <jats:styled-content style=\"fixed-case\">THV<\/jats:styled-content>s. Forty\u2010nine (78%) biopsies had injured <jats:styled-content style=\"fixed-case\">THV<\/jats:styled-content>s, and 10 (16%) were diagnosed with <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> (mean \u00b1 standard deviation of injured <jats:styled-content style=\"fixed-case\">THV<\/jats:styled-content>s\/biopsy: 90 \u00b1 9%). Biopsies diagnosed with other diseases also had injured <jats:styled-content style=\"fixed-case\">THV<\/jats:styled-content>s (36 \u00b1 33%). Biopsies from patients with cyclophosphamide plus fractionated total body irradiation conditioning and biopsies taken within 100 days post\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> had significantly more occluded <jats:styled-content style=\"fixed-case\">THV<\/jats:styled-content>s (respectively: 40 \u00b1 38%, <jats:italic>P<\/jats:italic> = 0.0188; and 35 \u00b1 35%, <jats:italic>P<\/jats:italic> = 0.0076) than those with other conditioning regimens or in biopsies taken &gt;100 days post\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. All biopsies taken at any time in the 6\u2010year post\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> period had similar amounts of <jats:styled-content style=\"fixed-case\">THV<\/jats:styled-content> phlebosclerosis (23 \u00b1 25%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate a high incidence of <jats:styled-content style=\"fixed-case\">THV<\/jats:styled-content> injuries resembling <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> in post\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> liver biopsies. <jats:styled-content style=\"fixed-case\">THV<\/jats:styled-content> injuries were detectable for several years post\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, and were concurrent with other diagnoses. Our results also suggest that <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> may be underdiagnosed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12887","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T09:10:57Z","timestamp":1444036257000},"page":"996-1003","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Terminal hepatic venule injury in liver biopsies of allogeneic haematopoietic stem cell recipients\u2014a study of 63 cases"],"prefix":"10.1111","volume":"68","author":[{"given":"Changqing","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine St Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M","family":"Brunt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine St Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05316.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198712000-00011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-4-199302150-00003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-23204"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190515"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90911-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040121"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23533"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.08.024"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.06.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.2012.01034.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260117"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290609"},{"key":"e_1_2_8_15_1","first-page":"285","article-title":"Veno\u2010occlusive disease of liver with nonportal type of cirrhosis, occurring in Hamaica","volume":"57","author":"Bras G","year":"1954","journal-title":"AMA Arch. 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