{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T12:45:24Z","timestamp":1776170724743,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T00:00:00Z","timestamp":1452124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Susan G Komen Postdoctoral Fellowship","award":["PDF14298348"],"award-info":[{"award-number":["PDF14298348"]}]},{"name":"Cancer Center Support Grant of the National Institutes of Health\/National Cancer Institute","award":["P30CA008748"],"award-info":[{"award-number":["P30CA008748"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Infiltrating epitheliosis is a rare complex sclerosing lesion (CSL) of the breast, characterized by infiltrating ducts immersed in a scleroelastotic stroma and filled with cells having architectural and cytological patterns reminiscent of those of usual ductal hyperplasia. In this study we sought to define the molecular characteristics of infiltrating epitheliosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Eight infiltrating epitheliosis, adjacent breast lesions (one usual ductal hyperplasia, one papilloma, one micropapillary ductal carcinoma <jats:italic>in situ<\/jats:italic> and one low\u2010grade adenosquamous carcinoma), and corresponding normal breast tissue from each case were microdissected and subjected to massively parallel sequencing analysis targeting all coding regions of 254 genes mutated recurrently in breast cancer and\/or related to <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair. Mutations in components of the <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K pathway were found in all infiltrating epitheliosis samples, seven of which harboured <jats:italic><jats:styled-content style=\"fixed-case\">PIK<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content><\/jats:italic> hotspot mutations, while the remaining case displayed a <jats:italic><jats:styled-content style=\"fixed-case\">PIK<\/jats:styled-content>3R1<\/jats:italic> somatic mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Somatic mutations affecting <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K pathway genes were found to be highly prevalent in infiltrating epitheliosis, suggesting that these lesions may be neoplastic rather than hyperplastic. The landscape of somatic genetic alterations found in infiltrating epitheliosis is similar to that of radial scars\/CSLs, suggesting that infiltrating epitheliosis may represent one end of this spectrum of lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12897","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T14:20:29Z","timestamp":1445696429000},"page":"1030-1039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Infiltrating epitheliosis of the breast: characterization of histological features, immunophenotype and genomic profile"],"prefix":"10.1111","volume":"68","author":[{"given":"Carey A","family":"Eberle","sequence":"first","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY 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