{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:31:20Z","timestamp":1789500680683,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The distinction between primary ovarian mucinous tumours and appendiceal mucinous neoplasms metastatic to the ovary can be challenging, given the overlap of morphological features and immunohistochemical expression of traditional markers. Special <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\u2010rich sequence\u2010binding protein 2 (<jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>2) has recently been described as a sensitive and specific marker of colorectal epithelium. This study was to determine its expression in appendiceal mucinous tumours and its role in their distinction from ovarian neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Immunohistochemistry was performed in tissue microarrays from 32 primary appendiceal mucinous tumours (25 low\u2010grade appendiceal mucinous neoplasms and seven adenocarcinomas) and 40 ovarian mucinous neoplasms (20 borderline tumours and 20 adenocarcinomas). Stains were interpreted as positive or negative by scoring intensity and distribution. <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>2 was positive in 93.8% of appendiceal tumours and in only one ovarian tumour; <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>2 was 97.5% specific for appendiceal origin. <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>20, <jats:styled-content style=\"fixed-case\">CDX<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>2 were strongly and diffusely positive in appendiceal tumours; ovarian tumours were also positive, but with a patchy distribution and mild intensity. <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>7 was expressed in 97.5% of ovarian tumours and in 31.2% of appendiceal tumours. <jats:styled-content style=\"fixed-case\">PAX<\/jats:styled-content>8 was positive in 70% of ovarian tumours, and negative in all appendiceal lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>2 is frequently expressed in appendiceal mucinous neoplasms. In the context of a mucinous neoplasm involving the ovary, any <jats:styled-content style=\"fixed-case\">SATB<\/jats:styled-content>2 positivity should raise the possibility of appendiceal origin. Expression of <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>20, <jats:styled-content style=\"fixed-case\">CDX<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>2 supports appendiceal origin only when diffuse and strong. These and other markers, such as <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>7 and <jats:styled-content style=\"fixed-case\">PAX<\/jats:styled-content>8, are recommended in the work\u2010up of ovarian mucinous tumours with any clinical or pathological features suggestive of secondary origin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12899","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T07:10:50Z","timestamp":1446793850000},"page":"977-987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Immunohistochemical characterization of appendiceal mucinous neoplasms and the value of special <scp>AT<\/scp>\u2010rich sequence\u2010binding protein 2 in their distinction from primary ovarian mucinous tumours"],"prefix":"10.1111","volume":"68","author":[{"given":"Sarah","family":"Strickland","sequence":"first","affiliation":[{"name":"Department of Pathology and 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