{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:19:14Z","timestamp":1760242754403},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T00:00:00Z","timestamp":1452643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Medullary carcinoma of the large bowel occurs mainly right\u2010sided in elderly females. The tumour is almost invariably microsatellite instable and has been associated with favourable outcome. Our study aimed to present three cases of medullary carcinoma originating from the small bowel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We describe three cases of small bowel medullary carcinoma. Two patients had coeliac disease, diagnosed at the ages of 79 and 71 years, respectively. The tumours showed the characteristic syncytial growth pattern with marked intratumoral lymphocytic inflammation. Loss of MutL homologue 1 (<jats:styled-content style=\"fixed-case\">MLH<\/jats:styled-content>1) [and postmeiotic segregation increased 2 (<jats:italic>S. cerevisiae<\/jats:italic>) <jats:styled-content style=\"fixed-case\">PMS<\/jats:styled-content>2] expression was observed in all cases, consistent with high\u2010level microsatellite instability. All tumours were negative for Epstein\u2013Barr virus. Follow\u2010up information was available for one patient, who is recurrence\u2010free 6 years after resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Medullary carcinoma of the small bowel is exceedingly rare. Our data and a review of the literature suggest that this tumour type is characteristic for coeliac disease and may be the histological type underlying small bowel cancers with high\u2010level microsatellite instability in patients with coeliac disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12908","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T15:24:49Z","timestamp":1448378689000},"page":"136-140","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Medullary carcinoma of the small bowel"],"prefix":"10.1111","volume":"69","author":[{"given":"Iva","family":"Brcic","sequence":"first","affiliation":[{"name":"Institute of Pathology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gieri","family":"Cathomas","sequence":"additional","affiliation":[{"name":"Institute of Pathology Kantonsspital Baselland Liestal Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Vanoli","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine San Matteo Hospital University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Jilek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine LKH Hochsteiermark Leoben Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Giuffrida","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine San Matteo Hospital University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cord","family":"Langner","sequence":"additional","affiliation":[{"name":"Institute of Pathology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v3.i3.33"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.03.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i33.11486"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2014.02.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2015.05.005"},{"key":"e_1_2_7_7_1","first-page":"3","article-title":"Carcinomas with Lymphoid Stroma within the Gastrointestinal Tract: Histology and Molecular Pathology","volume":"1","author":"Max N","year":"2016","journal-title":"J. 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