{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:20:02Z","timestamp":1788373202912,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To understand more clearly the genetic ontogeny of inverted papilloma of urinary bladder, we analysed telomerase reverse transcriptase (<jats:styled-content style=\"fixed-case\">TERT<\/jats:styled-content>) promoter mutation status in a group of 26 inverted papillomas in comparison with the mutation status of urothelial carcinoma with inverted growth (26 cases), conventional urothelial carcinoma (36 Ta non\u2010invasive urothelial carcinoma, 35 T2 invasive urothelial carcinoma) and cystitis glandularis (25 cases).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TERT<\/jats:styled-content> promoter mutations in inverted papilloma, urothelial carcinoma with inverted growth, urothelial carcinoma and cystitis glandularis were found in 15% (four of 26), 58% (15 of 26), 63% (45 of 71) and 0% (none of 25), respectively. C228T mutations were the predominant mutations (97%) found in bladder tumours, while C250T aberrations occurred in approximately 3% of bladder tumours. In the inverted papilloma group, <jats:styled-content style=\"fixed-case\">TERT<\/jats:styled-content> mutation occurred predominantly in female patients (<jats:italic>P<\/jats:italic> = 0.006). Among urothelial carcinomas, <jats:styled-content style=\"fixed-case\">TERT<\/jats:styled-content> promoter mutation status did not correlate with gender, histological grade or pathological stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TERT<\/jats:styled-content> promoter mutations were found in 15% of inverted papillomas. Our data suggest that there is a subpopulation of inverted papilloma that shares a carcinogenetic pathway with urothelial carcinoma with inverted growth and conventional urothelial carcinomas. Caution is warranted in exploring <jats:styled-content style=\"fixed-case\">TERT<\/jats:styled-content> promoter mutation status as a screening or adjunct diagnostic test for bladder cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12920","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T07:18:45Z","timestamp":1450423125000},"page":"107-113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Telomerase reverse transcriptase (<scp>TERT<\/scp>) promoter mutation analysis of benign, malignant and reactive urothelial lesions reveals a subpopulation of inverted papilloma with immortalizing genetic change"],"prefix":"10.1111","volume":"69","author":[{"given":"Liang","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN USA"},{"name":"Department of Urology Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell D","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lopez\u2010Beltran","sequence":"additional","affiliation":[{"name":"Department of Pathology Unit of Anatomical Pathology Cordoba Spain"},{"name":"Department of Surgery Faculty of Medicine Cordoba Spain"},{"name":"Champalimaud Clinical Center Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Montironi","sequence":"additional","affiliation":[{"name":"Institute of Pathological Anatomy and Histopathology School of Medicine Polytechnic University of the Marche Region (Ancona) United Hospitals Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puay\u2010Hoon","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology Singapore General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T","family":"MacLennan","sequence":"additional","affiliation":[{"name":"Department of Pathology Case Western Reserve University Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean R","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Henry Ford Health System Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN 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