{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T01:37:41Z","timestamp":1722994661178},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To report a case detailing the early histopathogenesis of Burkitt lymphoma (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>), Epstein\u2010Barr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>) positive, in the clinical setting of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We describe a 57 year\u2010old woman with newly diagnosed <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection who presented with unilateral localized axillary lymphadenopathy. Histopathological, immunohistochemical, and flow cytometric analyses were performed and showed <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive nests of Burkitt cells, including rare nests also positive for cytomegalovirus, exclusively located within hyperplastic monocytoid B\u2010cell areas of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> lymphadenitis. Due to positron emission tomography\/computed tomography findings of persistent localized lymphadenopathy with markedly increased fludeoxyglucose avidity a core needle biopsy was performed. Histopathological, immunohistochemical, fluorescence <jats:italic>in situ<\/jats:italic> hybridization, and flow cytometric analyses confirmed <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early histopathogenesis of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> occurred as nests of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive Burkitt cells within prominent monocytoid B\u2010cell areas in our case. The results equip the pathologist to identify a very subtle Burkitt microlymphoma which would allow for prompt and appropriate chemotherapeutic intervention and may promote research into the possible relationship between monocytoid B cells and <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12960","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T15:04:06Z","timestamp":1457449446000},"page":"516-521","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel insights into the early histopathogenesis of immunodeficiency\u2010associated Burkitt lymphoma: a case report of Burkitt microlymphoma arising within <scp>HIV<\/scp> lymphadenitis"],"prefix":"10.1111","volume":"69","author":[{"given":"David","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neval","family":"Ozkaya","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparna","family":"Hariharan","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,20]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"340","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Raphael M","year":"2008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.4.1406.004k26_1406_1412"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.7.2130"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31804d43d8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000172293.59785.b4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2007.apm_631.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.7.2331"},{"key":"e_1_2_9_9_1","first-page":"647518","article-title":"Human Herpesvirus\u20108 infection associated with Kaposi sarcoma, multicentric Castleman's disease, and plasmablastic microlymphoma in a man with AIDS: a case report with review of pathophysiologic proceses","volume":"2011","author":"Eaton C","year":"2010","journal-title":"Patholog. 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Int."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-269-8_2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000157942.26280.bf"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92740-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-599951"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12960","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T17:07:00Z","timestamp":1696266420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,20]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/his.12960"],"URL":"https:\/\/doi.org\/10.1111\/his.12960","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,20]]},"assertion":[{"value":"2016-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}