{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:04:25Z","timestamp":1773839065675,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T00:00:00Z","timestamp":1461715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Most colorectal polyps can be reliably assigned to one of the known polyp categories, but a subset of polyps named colonic mucosubmucosal elongated polyps (<jats:styled-content style=\"fixed-case\">CMSEP<\/jats:styled-content>s) do not fall into any of these categories. First described in the Japanese literature, <jats:styled-content style=\"fixed-case\">CMSEP<\/jats:styled-content>s seem to be under\u2010recognized in the Western literature. The aims of this study were to describe the clinicopathological features of 14 <jats:styled-content style=\"fixed-case\">CMSEP<\/jats:styled-content>s, discuss potential pathogenetic mechanisms, and increase awareness of this entity among pathologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Fourteen pedunculated colorectal polyps that met the histopathological criteria for <jats:styled-content style=\"fixed-case\">CMSEP<\/jats:styled-content> (as described by Matake <jats:italic>et al<\/jats:italic>. and Alizart <jats:italic>et al<\/jats:italic>.) were assessed (12 males and two females; mean age 59.7 years). Five polyps were located in the sigmoid colon, four in the rectum, two in the descending colon, and three in the colon not otherwise specified. Nine of 14 polyps were discovered incidentally: two of nine on routine screening colonoscopy, two of nine on surveillance colonoscopy for inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>), and five of nine upon surgical intervention for carcinoma or <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>. None coexisted with diverticular disease. The polyps were long and slender, varied from 5 to 30 mm in length (mean 15.9 mm), and showed a normal\u2010looking colonic mucosal layer and underlying loose submucosa with thick\u2010walled and congested blood vessels and lymphatics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CMSEP<\/jats:styled-content>s show subtle but distinctive pathological features, and occur in normal and diseased colons. Pathologists need to be aware of this entity, to avoid confusion with other more commonly encountered colorectal polyps. With increasing colon cancer screening programmes and surveillance colonoscopy, it is likely that <jats:styled-content style=\"fixed-case\">CMSEP<\/jats:styled-content>s will be encountered more often.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12969","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T02:15:58Z","timestamp":1458353758000},"page":"592-599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Colonic mucosubmucosal elongated polyp: report of a series of 14 cases and review of the literature"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5747-8900","authenticated-orcid":false,"given":"Rola H","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Medicine Kuwait University Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nissreen M","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Pathology Mubarak Al\u2010Kabeer Hospital Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of Pathology University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runjan","family":"Chetty","sequence":"additional","affiliation":[{"name":"Department of Pathology University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,27]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1330","article-title":"Long pedunculated colonic polyps composed of mucosa and submucosa: a report of four cases","volume":"29","author":"Matake H","year":"1994","journal-title":"Stomach Intest."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237307"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822c0688"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.087"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/94407232"},{"key":"e_1_2_8_7_1","first-page":"1940","article-title":"A case of enteric muco\u2010submucosal elongated polyp","volume":"109","author":"Nishimura J","year":"2012","journal-title":"Jpn. 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