{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:36:05Z","timestamp":1770233765880,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T00:00:00Z","timestamp":1462492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Aims<\/jats:title>Ectomesenchymal chondromyxoid tumour (ECT<\/jats:styled-content>) is a rare, benign intraoral neoplasm showing a predilection for the anterior dorsum of the tongue. The World Health Organization includes ECT<\/jats:styled-content> in the pathological spectrum of soft tissue myoepithelioma. EWS RNA<\/jats:styled-content>\u2010binding protein 1 gene (EWSR<\/jats:styled-content>1<\/jats:italic>) rearrangement is found in 45% of cutaneous, soft tissue and bone myoepithelial neoplasms, and pleomorphic adenoma gene 1 (PLAG<\/jats:styled-content>1<\/jats:italic>) aberrations are found in 37% of EWSR<\/jats:styled-content>1<\/jats:italic>\u2010negative soft tissue myoepitheliomas. The aim of this study was to evaluate the presence of EWSR<\/jats:styled-content>1<\/jats:italic> and PLAG<\/jats:styled-content>1<\/jats:italic> rearrangements in ECT<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>Eleven formalin\u2010fixed, paraffin\u2010embedded ECT<\/jats:styled-content>s were evaluated with fluorescence in\u2010situ<\/jats:italic> hybridization probes for EWSR<\/jats:styled-content>1<\/jats:italic> (22q12) and PLAG<\/jats:styled-content>1<\/jats:italic> (8q12). Among the 11 ECT<\/jats:styled-content>s tested, three (27.3%) showed EWSR<\/jats:styled-content>1<\/jats:italic> rearrangement in >15% of tumour cells, whereas eight (72.7%) cases did not show EWSR<\/jats:styled-content>1<\/jats:italic> rearrangement. Eight of nine (89%) ECT<\/jats:styled-content>s showed gain of EWSR<\/jats:styled-content>1<\/jats:italic>, probably representing gain of all or part of chromosome 22, in a varying proportion of neoplastic cells ranging between 1.4% and 27.9%. PLAG<\/jats:styled-content>1<\/jats:italic> rearrangement was not detected in the successfully hybridized tissue sections (7\/11). No correlation was observed between the molecular and histopathological findings, such as morphology of the neoplastic cells, the presence of atypia, and matrical type.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We identified EWSR<\/jats:styled-content>1<\/jats:italic> rearrangement in >25% of ECT<\/jats:styled-content>s. These results suggest that some ECT<\/jats:styled-content>s are at least genetically related to myoepithelioma of the soft parts. Finally, PLAG<\/jats:styled-content>1<\/jats:italic> aberrations do not appear to be critical in the pathogenesis of ECT<\/jats:styled-content> of the tongue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12973","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T11:05:46Z","timestamp":1458817546000},"page":"607-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A subset of ectomesenchymal chondromyxoid tumours of the tongue show EWSR<\/scp>1<\/i> rearrangements and are genetically linked to soft tissue myoepithelial neoplasms: a study of 11 cases"],"prefix":"10.1111","volume":"69","author":[{"given":"Prokopios P","family":"Argyris","sequence":"first","affiliation":[{"name":"Division of Oral and Maxillofacial Pathology School of Dentistry University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A","family":"Bilodeau","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Sciences University of Pittsburgh School of Dental Medicine Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron E","family":"Yancoskie","sequence":"additional","affiliation":[{"name":"Touro College of Dental Medicine at New York Medical College Valhalla NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Trochesset","sequence":"additional","affiliation":[{"name":"Department of Oral Biology and Pathology Stony Brook University School of Dental Medicine Stony Brook NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan E","family":"Pambuccian","sequence":"additional","affiliation":[{"name":"Department of Pathology Loyola University Medical Center Maywood IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Pathology School of Dentistry University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonal S","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Radiology and Medicine New York University College of Dentistry\u2014New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Edelman","sequence":"additional","affiliation":[{"name":"Department of Pathology Hofstra North Shore\u2010LIJ School of Medicine\u2014New Hyde Park NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Freedman","sequence":"additional","affiliation":[{"name":"Section of Oral Pathology New York Presbyterian\/Queens Flushing NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Dolan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota Medical School University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis G","family":"Koutlas","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Pathology School of Dentistry University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199505000-00003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-014-0578-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01447.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2012.11.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2003.07.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.07.007"},{"key":"e_1_2_8_8_1","first-page":"4685","article-title":"Ectomesenchymal chondromyxoid tumour of the tongue. 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