{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:02:09Z","timestamp":1792087329975,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We have encountered cases of a distinctive myxomatous alveolar wall thickening around pulmonary infarctions, and have termed it \u2018acute ischaemic lung injury\u2019 (<jats:styled-content style=\"fixed-case\">AILI<\/jats:styled-content>). In this study we determined if pulmonary infarction is the only cause of <jats:styled-content style=\"fixed-case\">AILI<\/jats:styled-content> and have elucidated its histological features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We examined 2941 cases that underwent lobectomy, surgical lung biopsies for nodular lesions or autopsies between 1994 and 2014. Cases were divided into pulmonary infarction and non\u2010infarction groups. The histological features of <jats:styled-content style=\"fixed-case\">AILI<\/jats:styled-content> sought were lobule\u2010based alveolar wall thickening (myxomatous or fibrous) with epithelial metaplasia and negligible inflammation. In order to characterize <jats:styled-content style=\"fixed-case\">AILI<\/jats:styled-content> further, we performed immunohistochemical staining using several antibodies. Thirty\u2010four of 69 cases in the infarction group (mean age 57.1 years, 30 males) had <jats:styled-content style=\"fixed-case\">AILI<\/jats:styled-content>, whereas only one (but with vascular obstruction) of the remaining 2872 in the non\u2010infraction group had <jats:styled-content style=\"fixed-case\">AILI<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">AILI<\/jats:styled-content> was located around infarctions. Separation of the epithelial and endothelial basement membranes of the alveolar wall was observed in 75% of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">AILI<\/jats:styled-content> is associated almost exclusively with lung infarction, caused presumably by vascular obstruction. We consider <jats:styled-content style=\"fixed-case\">AILI<\/jats:styled-content> to represent a distinct lung lesion other than pulmonary haemorrhage and infarction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12979","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T11:18:15Z","timestamp":1459768695000},"page":"647-654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute ischaemic lung injury due to pulmonary vascular obstruction"],"prefix":"10.1111","volume":"69","author":[{"given":"Yoshinori","family":"Kawabata","sequence":"first","affiliation":[{"name":"Division of Diagnostic Pathology Saitama Prefectural Cardiovascular and Respiratory Center Kumagaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Saitama Prefectural Cardiovascular and Respiratory Center Kumagaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eishin","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Saitama Prefectural Cardiovascular and Respiratory Center Kumagaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Ikeya","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Saitama Prefectural Cardiovascular and Respiratory Center Kumagaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Kurashima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Saitama Prefectural Cardiovascular and Respiratory Center Kumagaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Takayanagi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Saitama Prefectural Cardiovascular and Respiratory Center Kumagaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"305","article-title":"Correlation of postmortem chest teleroentgenograms with autopsy findings: with special reference to lung embolism and infarction","volume":"43","author":"Hampton AO","year":"1940","journal-title":"Am. 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