{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:15:24Z","timestamp":1789866924529,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To analyse the clinicopathological features and immunohistochemical characteristics of nine cases of salivary duct carcinoma (<jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>) with rhabdoid features (<jats:styled-content style=\"fixed-case\">SDCRF<\/jats:styled-content>), representing a new, extremely rare type of salivary gland malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We analysed 2511 cases of salivary gland tumour, clinicopathologically and immunohistochemically. The incidence of <jats:styled-content style=\"fixed-case\">SDCRF<\/jats:styled-content> was 0.4%. Eight patients were male. The age of patients ranged from 36 years to 85 years (mean, 61 years). <jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content> arose from the parotid glands and submandibular gland in six and three cases, respectively. Seven cases appeared as a carcinoma component of carcinoma ex pleomorphic adenoma cases. Six patients died of disease. Histologically, diffuse proliferations of non\u2010coherent large ovoid or polygonal carcinoma cells with eosinophilic cytoplasm and eccentric nuclei were observed in all cases; such cytological characteristics were defined as \u2018rhabdoid features\u2019. Immunohistochemically, all cases were positive for cytokeratin, gross cystic disease fluid protein\u201015, androgen receptor, and <jats:styled-content style=\"fixed-case\">SMARCB<\/jats:styled-content>1, seven cases were positive for <jats:styled-content style=\"fixed-case\">HER<\/jats:styled-content>2, and two cases were positive for epidermal growth factor receptor. However, all cases were negative for vimentin and myoepithelial markers. Eight cases showed no or aberrant expression of E\u2010cadherin and \u03b2\u2010catenin. The results suggest that <jats:styled-content style=\"fixed-case\">SDCRF<\/jats:styled-content> is an extremely rare subtype of <jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>, and not a sarcomatoid variant of <jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">SDCRF<\/jats:styled-content> is histologically unique, and is positive for <jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content> markers but negative for vimentin, unlike rhabdoid\u2010type carcinomas arising from other organs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The morphogenesis of <jats:styled-content style=\"fixed-case\">SDCRF<\/jats:styled-content> is related to no or aberrant expression of cell\u2013cell adhesion molecules. Therefore, <jats:styled-content style=\"fixed-case\">SDCRF<\/jats:styled-content> could be a salivary counterpart to pleomorphic lobular breast carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12987","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T07:52:33Z","timestamp":1460706753000},"page":"164-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Salivary duct carcinoma with rhabdoid features: a salivary counterpart of pleomorphic lobular carcinoma of the breast"],"prefix":"10.1111","volume":"70","author":[{"given":"Kimihide","family":"Kusafuka","sequence":"first","affiliation":[{"name":"Pathology Division Shizuoka Cancer Centre Sunto Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Pathology Division Shizuoka Cancer Centre Sunto Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matsuyoshi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Toyohashi Municipal Hospital Toyohashi Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yamanegi","sequence":"additional","affiliation":[{"name":"Department of Pathology Hyogo College of Medicine Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hamamatsu University School of Medicine Hospital Hamamatsu Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology and Molecular Diagnostics Nagoya City University Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology and Molecular Diagnostics Nagoya City University Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Pathology Division Shizuoka Cancer Centre Sunto Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197705)39:5<2209::AID-CNCR2820390540>3.0.CO;2-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12454"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000413"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80221-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1309\/5J4008QRY1HWW5W4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2004.12.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200403000-00004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200308000-00004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02136.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.12.021"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000128662.66321.be"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200608000-00013"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-009-0479-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0460-1"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03135.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23466"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.9984"},{"key":"e_1_2_9_19_1","first-page":"236","volume-title":"Tumours of the salivary glands. World Health Organization classification of head and neck tumours: pathology and genetics","author":"Brandwein\u2010Gensler MS","year":"2005"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04252.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.d01-436.x"},{"key":"e_1_2_9_22_1","first-page":"1","article-title":"Primary CNS malignant rhabdoid tumor (MRT): report of two cases and review of literature","volume":"10","author":"Chou SM","year":"1991","journal-title":"Clin. Neuropathol."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0035-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199308000-00006"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2003.07.019"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.10.002"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.5858\/2005-129-e55-RTOTTG","article-title":"Rhabdoid tumor of the thyroid gland: a variant of anaplastic carcinoma","volume":"129","author":"Lai ML","year":"2005","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"1","key":"e_1_2_9_28_1","first-page":"pS16","article-title":"Salivary duct carcinoma with rhabdoid features is an extremely rare subtype of salivary duct carcinoma: down\u2010regulation of E\u2010cadherin expression","volume":"467","author":"Kusafuka K","year":"2015","journal-title":"Virchows Arch."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPS54RTFCTHGWX"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21854"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.160"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.06.006"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880416"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.01890.x"},{"key":"e_1_2_9_35_1","first-page":"987","article-title":"Correlation of E\u2010cadherin expression with differentiation grade and histological type in breast carcinoma","volume":"142","author":"Gamallo C","year":"1993","journal-title":"Am. J. Pathol."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182918a2b"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318158d6c5"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0603-RS"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000236"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000285"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000173"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2004.03.008"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-014-0556-2"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.12987","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.12987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:28:04Z","timestamp":1696314484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.12987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,8]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/his.12987"],"URL":"https:\/\/doi.org\/10.1111\/his.12987","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,8]]},"assertion":[{"value":"2016-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}